Detailed information of TA system TA105895

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ralRA/-
• Location: 5039833..5040204
• Replicon: chromosome
• Accession: NZ_CP029579
• Organism: Escherichia coli strain DA33137

Toxin (Protein)

• Gene name: ralR
• Uniprot ID: A0A0D6ZRD3
• Locus tag: DLJ64_RS26045
• Protein ID: WP_001443846.1
• Coordinates: 5040055..5040204 (-)
• Length: 50 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	5039833..5040011 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DLJ64_RS26020	5035788..5037161	+	1374	WP_000123748.1	ATP-dependent RNA helicase DbpA	-
DLJ64_RS26025	5037290..5038225	-	936	WP_001523172.1	tRNA 2-thiocytidine(32) synthetase TtcA	-
DLJ64_RS26030	5038277..5039512	-	1236	WP_000040839.1	site-specific integrase	-
DLJ64_RS26035	5039514..5039729	-	216	WP_000079604.1	excisionase XisR	-
DLJ64_RS26040	5039829..5040017	-	189	WP_001302840.1	DUF1187 family protein	-
-	5039833..5040011	+	179	NuclAT_0	-	Antitoxin
-	5039833..5040011	+	179	NuclAT_0	-	Antitoxin
-	5039833..5040011	+	179	NuclAT_0	-	Antitoxin
-	5039833..5040011	+	179	NuclAT_0	-	Antitoxin
DLJ64_RS26045	5040055..5040204	-	150	WP_001443846.1	type I toxin-antitoxin system endodeoxyribonuclease toxin RalR	Toxin
DLJ64_RS26050	5040260..5041069	-	810	WP_000166313.1	recombination protein RecT	-
DLJ64_RS26055	5041062..5043662	-	2601	WP_110074659.1	exodeoxyribonuclease VIII	-
DLJ64_RS26060	5043764..5044039	-	276	WP_001344816.1	hypothetical protein	-
DLJ64_RS26065	5044114..5044284	-	171	WP_001352098.1	conserved protein, Rac prophage	-
DLJ64_RS26070	5044284..5044505	-	222	WP_000560223.1	killing protein KilR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	5003366..5085278	81912

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Endodeoxyribonuclease toxin RalR (6-48)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5383.12 Da
• Isoelectric Point: 8.3398

>T105895 WP_001443846.1 NZ_CP029579:c5040204-5040055 [Escherichia coli]
MRYDNVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYGGSEKEALER

Nucleotide

• Length: 150 bp

>T105895 NZ_CP029579:c5040204-5040055 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT105895 NZ_CP029579:5039833-5040011 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Structures

Toxin

• AlphaFold DB: A0A0D6ZRD3

Antitoxin