105851

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4790289..4791607 Replicon chromosome
Accession NZ_CP029576
Organism Escherichia coli strain DA33135

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag DLJ63_RS24770 Protein ID WP_001262467.1
Coordinates 4790600..4791607 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag DLJ63_RS24765 Protein ID WP_001312177.1
Coordinates 4790289..4790600 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DLJ63_RS24740 4785821..4786840 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
DLJ63_RS24745 4786850..4787752 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
DLJ63_RS24750 4787763..4788746 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
DLJ63_RS24755 4788743..4789756 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
DLJ63_RS24760 4789981..4790304 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
DLJ63_RS24765 4790289..4790600 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
DLJ63_RS24770 4790600..4791607 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
DLJ63_RS24775 4791624..4792895 - 1272 WP_001545666.1 amino acid permease -
- 4793257..4793322 - 66 NuclAT_27 - -
- 4793257..4793322 - 66 NuclAT_27 - -
- 4793257..4793322 - 66 NuclAT_27 - -
- 4793257..4793322 - 66 NuclAT_27 - -
DLJ63_RS24790 4793371..4793478 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 4793740..4793797 - 58 NuclAT_26 - -
- 4793740..4793797 - 58 NuclAT_26 - -
- 4793740..4793797 - 58 NuclAT_26 - -
- 4793740..4793797 - 58 NuclAT_26 - -
DLJ63_RS24800 4793854..4793961 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
DLJ63_RS24810 4794337..4794444 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
DLJ63_RS24815 4794530..4796209 - 1680 Protein_4537 cellulose biosynthesis protein BcsG -
DLJ63_RS24820 4796206..4796397 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T105851 WP_001262467.1 NZ_CP029576:4790600-4791607 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T105851 NZ_CP029576:4790600-4791607 [Escherichia coli]
ATGGCGAATTGTCGTATTCTGTTAACGCCGTTGAATGAACGTGACGAACAGCGCGGATATTCGACACAGGGGTTGAAGCG
ACTGAGCGGCACTGCAAAATTGACCCCCAGGCTGGGGTTTACGCGAACTCAGTTTGTGCAGGAACTTCCGCGTCAACAAA
AAGGGATGAGTATTTCCGGTTACCAGCCCAAATTGCAATTAGTGCTGGATGAAGGAGAGTTCCGCGTCGTAGATCATCAG
GGAAATTTTATCCTTAAGCCCTCTCCAGCCGACTTTCCCGGTTTGGCCGAAAATGAACACGCAACAATGACATTGATGTC
TCGTTTGGGATTTGACGTACCTGTGCATGGCCTGTTGAGTTTTGCACCACAATCAGAGGAAGAGCTTGAATACGCATTTG
TTATCCGGCGCTATGACCGGGATAACAAGGGGCTGCCAGTGCATCAGGAACAGCTTGATGGCGCGATGCAGATTATGGAT
AAATATGGCAAAACGGGGAATGATAACGAACAATATGTCAGCTATGAAACGCTGGCCCGATTTTTAGTTGCCCATGTTAA
CGACAACATCGCATTTAAAATCGATCTCTTTCGTCGCATTGTTTACGCCTGGTTGCTGGGTAATAACGACATGCATTTAC
GAAACTTTGGCTTAGTGTACTCCGATGGTTTGACGCCAGCGTTAGCGCCGGTGTATGACTTTGTTTCTGTCGCTCCCTAT
CCGGAATATTTTCACTCAAACTATCTGGCGCTGCCGTTATTGACGCGAGAAGAAGGCGGTCGGGAGCTGGCTCCTGGATT
TCACAGTGATTATGGCGAGTATATCGGGCAGGACTTTTTGCTGTTGGGTGAATCAATGGGGTTAGCGCCCAGATTGCTGG
AAAAACTCTTTCAGGATATACGTAAAGAAAATGCCATTGTTATGGAAACGTATGAGCAGTCCTTTATGACTCAGGATCAT
ATCCAGGCTGTGCTGCAATGCTATCGACATCGTCTGGGGCTGCTGTGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT105851 WP_001312177.1 NZ_CP029576:4790289-4790600 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT105851 NZ_CP029576:4790289-4790600 [Escherichia coli]
ATGCATCGGCGAGTGAAAGTGTTGCTCTATGGTCAGGTAGTGGGTGAACTCTCTCAGAACGACAGTGGTTTTTTGTTCCA
GTATGCCCCGGATTACCACGGACCGGCAATCTCAATCAGCCTGCCCGTCGCACAGCGTCAGTTTCCCAGTGAGATGTTGC
ATCCTTATTTCGCCTCACTGGCGCCAGAAGGATGGCTGCGTCAACGCTACAGCCAGATACAGCATCGTGACGAAAACGAT
CTGCTGGGAATGCTTATTGATAACGGCAAGAATCTGCTGGGGGCCATCCAGATTTTACCTTGGGAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References