Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 121338..121592 Replicon plasmid pDA33133-157
Accession NZ_CP029575
Organism Escherichia coli strain DA33133

Toxin (Protein)


Gene name srnB Uniprot ID -
Locus tag DLJ62_RS25320 Protein ID WP_015387399.1
Coordinates 121386..121592 (+) Length 69 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 121338..121399 (-)

Genomic Context

DLJ62_RS25270DLJ62_RS25285DLJ62_RS25290DLJ62_RS25295DLJ62_RS25310DLJ62_RS25320DLJ62_RS25325DLJ62_RS25335DLJ62_RS25340DLJ62_RS25350DLJ62_RS25355DLJ62_RS25995DLJ62_RS25300-----DLJ62_RS25345
Location: 116990..117202 (213 bp)
Type: Others
Protein ID: WP_005012601.1
Location: 117647..118324 (678 bp)
Type: Others
Protein ID: WP_001339397.1
Location: 118324..118671 (348 bp)
Type: Others
Protein ID: WP_000624622.1
Location: 118691..120262 (1572 bp)
Type: Others
Protein ID: WP_023149734.1
Location: 121017..121199 (183 bp)
Type: Others
Protein ID: WP_000968309.1
Location: 121386..121592 (207 bp)
Type: Toxin
Protein ID: WP_015387399.1
Location: 121876..122133 (258 bp)
Type: Others
Protein ID: WP_000083833.1
Location: 122369..122443 (75 bp)
Type: Others
Protein ID: WP_032336874.1
Location: 122436..122882 (447 bp)
Type: Others
Protein ID: Protein_150
Location: 124203..125423 (1221 bp)
Type: Others
Protein ID: WP_000410951.1
Location: 125434..126345 (912 bp)
Type: Others
Protein ID: WP_000440183.1
Location: 117503..117592 (90 bp)
Type: Others
Protein ID: Protein_141
Location: 120300..120916 (617 bp)
Type: Others
Protein ID: Protein_145
Location: 121338..121399 (62 bp)
Type: Antitoxin
Protein ID: NuclAT_2
Location: 121338..121399 (62 bp)
Type: Antitoxin
Protein ID: NuclAT_2
Location: 121338..121399 (62 bp)
Type: Antitoxin
Protein ID: NuclAT_2
Location: 121338..121399 (62 bp)
Type: Antitoxin
Protein ID: NuclAT_2
Location: 122828..123310 (483 bp)
Type: Others
Protein ID: Protein_151
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DLJ62_RS25270116990..117202+213WP_005012601.1hypothetical protein-
DLJ62_RS25995117503..117592-90Protein_141IS1 family transposase-
DLJ62_RS25285117647..118324+678WP_001339397.1IS66 family insertion sequence hypothetical protein-
DLJ62_RS25290118324..118671+348WP_000624622.1IS66 family insertion sequence element accessory protein TnpB-
DLJ62_RS25295118691..120262+1572WP_023149734.1IS66 family transposase-
DLJ62_RS25300120300..120916-617Protein_145IS1 family transposase-
DLJ62_RS25310121017..121199+183WP_000968309.1hypothetical protein-
-121338..121399-62NuclAT_2-Antitoxin
-121338..121399-62NuclAT_2-Antitoxin
-121338..121399-62NuclAT_2-Antitoxin
-121338..121399-62NuclAT_2-Antitoxin
DLJ62_RS25320121386..121592+207WP_015387399.1type I toxin-antitoxin system Hok family toxinToxin
DLJ62_RS25325121876..122133+258WP_000083833.1replication regulatory protein RepA-
DLJ62_RS25335122369..122443+75WP_032336874.1RepA leader peptide Tap-
DLJ62_RS25340122436..122882+447Protein_150incFII family plasmid replication initiator RepA-
DLJ62_RS25345122828..123310-483Protein_151VENN motif pre-toxin domain-containing protein-
DLJ62_RS25350124203..125423+1221WP_000410951.1arginine deiminase-
DLJ62_RS25355125434..126345+912WP_000440183.1carbamate kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmiderm(B) / blaCTX-M-15 / aac(3)-IId / mph(A) / sul1 / qacE / aadA5 / dfrA17 / aac(6')-Ib-cr / blaOXA-1-1..156518156518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(23-64)


Sequences

Toxin        


Download         Length: 69 a.a.        Molecular weight: 7720.23 Da        Isoelectric Point: 9.3127

>T105823 WP_015387399.1 NZ_CP029575:121386-121592 [Escherichia coli]
MKYLNTTDCSLFLAGRSKFMTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK

Download         Length: 207 bp

>T105823 NZ_CP029575:121386-121592 [Escherichia coli]
ATGAAGTACCTTAACACTACTGATTGTAGCCTCTTCCTTGCAGGGAGGTCAAAGTTTATGACGAAATATGCCCTTATCGG
GTTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTTATGTGAACTGAATATTCACAGGG
GAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 62 bp

>AT105823 NZ_CP029575:c121399-121338 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

Download structure file

References