Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 81284..81517 Replicon plasmid pDA33133-157
Accession NZ_CP029575
Organism Escherichia coli strain DA33133

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag DLJ62_RS25065 Protein ID WP_001312861.1
Coordinates 81359..81517 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 81284..81315 (+)

Genomic Context

DLJ62_RS25025DLJ62_RS25035DLJ62_RS25040DLJ62_RS25045DLJ62_RS25050DLJ62_RS25055----DLJ62_RS25060-----DLJ62_RS25065DLJ62_RS25080DLJ62_RS25085DLJ62_RS25095DLJ62_RS25100DLJ62_RS25845DLJ62_RS25090
Location: 76573..77277 (705 bp)
Type: Others
Protein ID: WP_001067858.1
Location: 77405..77902 (498 bp)
Type: Others
Protein ID: WP_042039995.1
Location: 77970..78203 (234 bp)
Type: Others
Protein ID: WP_000005990.1
Location: 78231..78428 (198 bp)
Type: Others
Protein ID: Protein_96
Location: 78483..78917 (435 bp)
Type: Others
Protein ID: WP_000845937.1
Location: 78914..79633 (720 bp)
Type: Others
Protein ID: WP_001276238.1
Location: 79645..79842 (198 bp)
Type: Others
Protein ID: NuclAT_0
Location: 79645..79842 (198 bp)
Type: Others
Protein ID: NuclAT_0
Location: 79645..79842 (198 bp)
Type: Others
Protein ID: NuclAT_0
Location: 79645..79842 (198 bp)
Type: Others
Protein ID: NuclAT_0
Location: 79890..81259 (1370 bp)
Type: Others
Protein ID: WP_085947770.1
Location: 81284..81315 (32 bp)
Type: Antitoxin
Protein ID: NuclAT_1
Location: 81284..81315 (32 bp)
Type: Antitoxin
Protein ID: NuclAT_1
Location: 81284..81315 (32 bp)
Type: Antitoxin
Protein ID: NuclAT_1
Location: 81284..81315 (32 bp)
Type: Antitoxin
Protein ID: NuclAT_1
Location: 81359..81517 (159 bp)
Type: Toxin
Protein ID: WP_001312861.1
Location: 82438..82725 (288 bp)
Type: Others
Protein ID: WP_000107535.1
Location: 82843..83664 (822 bp)
Type: Others
Protein ID: WP_001234426.1
Location: 84884..85267 (384 bp)
Type: Others
Protein ID: WP_001151524.1
Location: 85454..86143 (690 bp)
Type: Others
Protein ID: WP_000283385.1
Location: 79645..79833 (189 bp)
Type: Others
Protein ID: WP_001299721.1
Location: 83961..84563 (603 bp)
Type: Others
Protein ID: WP_013362798.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DLJ62_RS2502576573..77277+705WP_001067858.1IS6-like element IS26 family transposase-
DLJ62_RS2503577405..77902+498WP_042039995.1single-stranded DNA-binding protein-
DLJ62_RS2504077970..78203+234WP_000005990.1DUF905 family protein-
DLJ62_RS2504578231..78428+198Protein_96hypothetical protein-
DLJ62_RS2505078483..78917+435WP_000845937.1conjugation system SOS inhibitor PsiB-
DLJ62_RS2505578914..79633+720WP_001276238.1plasmid SOS inhibition protein A-
DLJ62_RS2584579645..79833-189WP_001299721.1hypothetical protein-
-79645..79842+198NuclAT_0--
-79645..79842+198NuclAT_0--
-79645..79842+198NuclAT_0--
-79645..79842+198NuclAT_0--
DLJ62_RS2506079890..81259+1370WP_085947770.1IS3-like element IS150 family transposase-
-81284..81315+32NuclAT_1-Antitoxin
-81284..81315+32NuclAT_1-Antitoxin
-81284..81315+32NuclAT_1-Antitoxin
-81284..81315+32NuclAT_1-Antitoxin
DLJ62_RS2506581359..81517+159WP_001312861.1type I toxin-antitoxin system Hok family toxinToxin
DLJ62_RS2508082438..82725+288WP_000107535.1hypothetical protein-
DLJ62_RS2508582843..83664+822WP_001234426.1DUF945 domain-containing protein-
DLJ62_RS2509083961..84563-603WP_013362798.1transglycosylase SLT domain-containing protein-
DLJ62_RS2509584884..85267+384WP_001151524.1relaxosome protein TraM-
DLJ62_RS2510085454..86143+690WP_000283385.1conjugal transfer transcriptional regulator TraJ-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmiderm(B) / blaCTX-M-15 / aac(3)-IId / mph(A) / sul1 / qacE / aadA5 / dfrA17 / aac(6')-Ib-cr / blaOXA-1-1..156518156518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(8-48)


Sequences

Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T105819 WP_001312861.1 NZ_CP029575:81359-81517 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T105819 NZ_CP029575:81359-81517 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 32 bp

>AT105819 NZ_CP029575:81284-81315 [Escherichia coli]
CACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBP11895

Antitoxin

Download structure file

References