Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1985959..1986653 Replicon chromosome
Accession NZ_CP029574
Organism Escherichia coli strain DA33133

Toxin (Protein)


Gene name yafO Uniprot ID Q47157
Locus tag DLJ62_RS10155 Protein ID WP_001263489.1
Coordinates 1986255..1986653 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1QAE3
Locus tag DLJ62_RS10150 Protein ID WP_000554758.1
Coordinates 1985959..1986252 (+) Length 98 a.a.

Genomic Context

DLJ62_RS10130DLJ62_RS10140DLJ62_RS10145DLJ62_RS10150DLJ62_RS10155DLJ62_RS10160DLJ62_RS10165DLJ62_RS10170DLJ62_RS10180----DLJ62_RS10135DLJ62_RS10175
Location: 1981591..1982088 (498 bp)
Type: Others
Protein ID: WP_000006255.1
Location: 1983996..1984781 (786 bp)
Type: Others
Protein ID: WP_000207552.1
Location: 1984852..1985907 (1056 bp)
Type: Others
Protein ID: WP_001226164.1
Location: 1985959..1986252 (294 bp)
Type: Antitoxin
Protein ID: WP_000554758.1
Location: 1986255..1986653 (399 bp)
Type: Toxin
Protein ID: WP_001263489.1
Location: 1986663..1987115 (453 bp)
Type: Others
Protein ID: WP_001059892.1
Location: 1987433..1987639 (207 bp)
Type: Others
Protein ID: Protein_1834
Location: 1987635..1988156 (522 bp)
Type: Others
Protein ID: Protein_1835
Location: 1989931..1990389 (459 bp)
Type: Others
Protein ID: WP_001291990.1
Location: 1990985..1991065 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1990985..1991065 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1990985..1991065 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1990985..1991065 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1982312..1984024 (1713 bp)
Type: Others
Protein ID: Protein_1828
Location: 1988213..1989670 (1458 bp)
Type: Others
Protein ID: WP_001292994.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
DLJ62_RS101301981591..1982088+498WP_000006255.1REP-associated tyrosine transposase RayT-
DLJ62_RS101351982312..1984024-1713Protein_1828flagellar biosynthesis protein FlhA-
DLJ62_RS101401983996..1984781+786WP_000207552.1putative lateral flagellar export/assembly protein LafU-
DLJ62_RS101451984852..1985907+1056WP_001226164.1DNA polymerase IV-
DLJ62_RS101501985959..1986252+294WP_000554758.1type I toxin-antitoxin system antitoxin YafNAntitoxin
DLJ62_RS101551986255..1986653+399WP_001263489.1type II toxin-antitoxin system mRNA interferase toxin YafOToxin
DLJ62_RS101601986663..1987115+453WP_001059892.1GNAT family N-acetyltransferase-
DLJ62_RS101651987433..1987639+207Protein_1834RtcB family protein-
DLJ62_RS101701987635..1988156+522Protein_1835peptide chain release factor H-
DLJ62_RS101751988213..1989670-1458WP_001292994.1cytosol nonspecific dipeptidase-
DLJ62_RS101801989931..1990389+459WP_001291990.1xanthine phosphoribosyltransferase-
-1990985..1991065+81NuclAT_12--
-1990985..1991065+81NuclAT_12--
-1990985..1991065+81NuclAT_12--
-1990985..1991065+81NuclAT_12--

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideGenomic island-gmhA/lpcA1971374..200494133567


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15487.84 Da        Isoelectric Point: 7.4215

>T105803 WP_001263489.1 NZ_CP029574:1986255-1986653 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANENNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKLARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T105803 NZ_CP029574:1986255-1986653 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.76 Da        Isoelectric Point: 5.2170

>AT105803 WP_000554758.1 NZ_CP029574:1985959-1986252 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EQYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT105803 NZ_CP029574:1985959-1986252 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A090J8B1

Antitoxin

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Source
ID
Structure
AlphaFold DBS1QAE3

References