Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1957176..1957689 Replicon chromosome
Accession NZ_CP029561
Organism Streptococcus agalactiae strain 32790-3A

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DX49
Locus tag DKY66_RS10270 Protein ID WP_000481712.1
Coordinates 1957176..1957430 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q8DX48
Locus tag DKY66_RS10275 Protein ID WP_000387490.1
Coordinates 1957423..1957689 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKY66_RS10250 1952940..1955441 - 2502 WP_000239414.1 ATP-binding protein -
DKY66_RS10255 1955462..1955872 - 411 WP_000390747.1 conjugal transfer protein -
DKY66_RS10260 1955883..1956149 - 267 WP_001055037.1 hypothetical protein -
DKY66_RS10265 1956170..1957123 - 954 WP_000565540.1 conjugal transfer protein -
DKY66_RS10270 1957176..1957430 - 255 WP_000481712.1 Txe/YoeB family addiction module toxin Toxin
DKY66_RS10275 1957423..1957689 - 267 WP_000387490.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DKY66_RS10280 1957834..1958307 - 474 WP_000560386.1 hypothetical protein -
DKY66_RS10285 1958315..1958797 - 483 WP_000383283.1 antirestriction protein ArdA -
DKY66_RS10290 1958850..1959122 - 273 WP_000017154.1 hypothetical protein -
DKY66_RS10295 1959257..1959826 - 570 WP_000010056.1 hypothetical protein -
DKY66_RS10300 1959829..1961178 - 1350 WP_000491712.1 AAA family ATPase -
DKY66_RS10305 1961375..1961674 - 300 WP_000737133.1 helix-turn-helix domain-containing protein -
DKY66_RS10310 1961658..1962035 - 378 WP_000287186.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - cfa/cfb / cfa/cfb 1946746..2022976 76230


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10445.87 Da        Isoelectric Point: 6.7282

>T105780 WP_000481712.1 NZ_CP029561:c1957430-1957176 [Streptococcus agalactiae]
MFNFTEEAWKDYVSWQQEDKKILKRINRLIEDIKRDPFEGIGKPEPLKYHYSGAWSRRITEEHRLIYMIEDGEIYFLSFR
DHYK

Download         Length: 255 bp

>T105780 NZ_CP029561:c1957430-1957176 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10316.70 Da        Isoelectric Point: 4.6742

>AT105780 WP_000387490.1 NZ_CP029561:c1957689-1957423 [Streptococcus agalactiae]
MEAIVYSHFRNNLKDYMKKVNDEFEPLIVVNKNPDENIVVLSQDSWESLQETIRLMENDYLSHKVINGISQVKEKQVTKH
GLIEVEDV

Download         Length: 267 bp

>AT105780 NZ_CP029561:c1957689-1957423 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829IC12

Antitoxin

Source ID Structure
AlphaFold DB A0A829I9V6

References