Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2301425..2302068 Replicon chromosome
Accession NZ_CP029553
Organism Methylobacterium terrae strain 17Sr1-28

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DK419_RS10300 Protein ID WP_109958998.1
Coordinates 2301787..2302068 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DK419_RS10295 Protein ID WP_109958997.1
Coordinates 2301425..2301739 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DK419_RS10280 2298080..2299402 - 1323 WP_109958994.1 histidine kinase -
DK419_RS10285 2299475..2300767 - 1293 WP_109958995.1 adenylosuccinate synthase -
DK419_RS10290 2300933..2301295 - 363 WP_109958996.1 hypothetical protein -
DK419_RS10295 2301425..2301739 - 315 WP_109958997.1 HigA family addiction module antidote protein Antitoxin
DK419_RS10300 2301787..2302068 - 282 WP_109958998.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DK419_RS10305 2302273..2303124 - 852 WP_109958999.1 D-amino-acid transaminase -
DK419_RS10310 2303322..2304248 + 927 WP_109959000.1 dihydrodipicolinate synthase family protein -
DK419_RS10315 2304257..2304538 - 282 WP_109959001.1 XRE family transcriptional regulator -
DK419_RS10320 2304784..2306094 - 1311 WP_109959002.1 adenylosuccinate lyase -
DK419_RS10325 2306449..2306751 + 303 WP_109962229.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10534.05 Da        Isoelectric Point: 9.0487

>T105768 WP_109958998.1 NZ_CP029553:c2302068-2301787 [Methylobacterium terrae]
VIRSFADSWTRDVFEGRSPKGIPAAILKTARRKLNYLDAATSLDALKAPPGDKLHPLIGERAGQRAIWINVQFRLCFRWT
ETGPEDVEIVDYH

Download         Length: 282 bp

>T105768 NZ_CP029553:c2302068-2301787 [Methylobacterium terrae]
GTGATCCGCAGCTTTGCCGATAGCTGGACCCGGGACGTCTTCGAGGGGCGAAGCCCAAAGGGCATCCCGGCTGCCATTCT
CAAGACGGCCCGGCGCAAGCTCAATTATCTCGACGCGGCGACCTCGCTCGACGCCTTGAAGGCCCCGCCGGGCGACAAGT
TGCACCCGTTGATTGGCGAGCGAGCCGGGCAGCGCGCCATCTGGATCAACGTCCAGTTCCGGCTGTGCTTCCGCTGGACC
GAGACCGGACCGGAAGACGTCGAGATCGTGGACTATCACTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11811.61 Da        Isoelectric Point: 4.9061

>AT105768 WP_109958997.1 NZ_CP029553:c2301739-2301425 [Methylobacterium terrae]
MSTENETVLPPMHPGEVLREEFMVPLNLTAYAIAKACRVPRTRIERIAREEIGITADTALRLGRYFGMDPQVWVNLQSRF
DLLTARNAIGEEMDEIRPLERAAA

Download         Length: 315 bp

>AT105768 NZ_CP029553:c2301739-2301425 [Methylobacterium terrae]
ATGAGCACAGAGAACGAGACCGTCCTGCCACCGATGCATCCGGGCGAGGTGCTGCGGGAGGAATTCATGGTTCCGCTGAA
CTTGACGGCGTATGCGATCGCGAAGGCGTGCCGCGTGCCGCGCACGCGGATCGAGCGCATCGCCCGCGAGGAGATCGGCA
TCACCGCCGATACGGCCTTGAGGCTCGGACGCTACTTCGGGATGGACCCACAGGTGTGGGTGAACCTTCAGAGTCGCTTC
GATCTTCTGACGGCCCGCAACGCGATCGGTGAGGAGATGGATGAGATCCGGCCGCTGGAGCGAGCGGCCGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References