Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 708102..708795 Replicon chromosome
Accession NZ_CP029492
Organism Escherichia coli strain HS30-1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag DKQ63_RS03745 Protein ID WP_000415584.1
Coordinates 708102..708398 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag DKQ63_RS03750 Protein ID WP_000650107.1
Coordinates 708400..708795 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKQ63_RS03705 703189..703503 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
DKQ63_RS03710 703534..704115 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
DKQ63_RS03720 704434..704767 + 334 Protein_668 DUF2645 family protein -
DKQ63_RS03725 704813..706162 - 1350 WP_001618857.1 two-component system sensor histidine kinase QseC -
DKQ63_RS03730 706159..706818 - 660 WP_001221493.1 two-component system response regulator QseB -
DKQ63_RS03735 706970..707362 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
DKQ63_RS03740 707415..707897 + 483 WP_000183505.1 transcriptional regulator -
DKQ63_RS03745 708102..708398 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
DKQ63_RS03750 708400..708795 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
DKQ63_RS03760 708928..710535 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
DKQ63_RS03765 710673..712931 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T105732 WP_000415584.1 NZ_CP029492:708102-708398 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T105732 NZ_CP029492:708102-708398 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT105732 WP_000650107.1 NZ_CP029492:708400-708795 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT105732 NZ_CP029492:708400-708795 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References