Detailed information of TA system TA105713

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1417534..1418054
• Replicon: chromosome
• Accession: NZ_CP029487
• Organism: Eubacterium maltosivorans strain YI

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CPZ25_RS06920
• Protein ID: WP_096920712.1
• Coordinates: 1417534..1417806 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CPZ25_RS06925
• Protein ID: WP_096920711.1
• Coordinates: 1417800..1418054 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CPZ25_RS06915	1416960..1417463	-	504	WP_096920713.1	hypothetical protein	-
CPZ25_RS06920	1417534..1417806	-	273	WP_096920712.1	Txe/YoeB family addiction module toxin	Toxin
CPZ25_RS06925	1417800..1418054	-	255	WP_096920711.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CPZ25_RS06930	1418135..1418746	-	612	WP_096920710.1	bacteriophage Gp15 family protein	-
CPZ25_RS06935	1418706..1419182	-	477	WP_096920709.1	hypothetical protein	-
CPZ25_RS06940	1419304..1419795	-	492	WP_096920708.1	hypothetical protein	-
CPZ25_RS06945	1419799..1420260	-	462	WP_096920707.1	chloramphenicol resistance protein	-
CPZ25_RS06950	1420241..1420630	-	390	WP_096920706.1	hypothetical protein	-
CPZ25_RS06955	1420630..1421055	-	426	WP_096920705.1	hypothetical protein	-
CPZ25_RS06960	1421065..1421442	-	378	WP_096920704.1	phage gp6-like head-tail connector protein	-
CPZ25_RS06965	1421451..1421762	-	312	WP_096920703.1	hypothetical protein	-
CPZ25_RS06970	1421772..1422050	-	279	WP_096920702.1	hypothetical protein	-
CPZ25_RS06975	1422065..1423006	-	942	WP_096920701.1	P2 family phage major capsid protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1393039..1454939	61900

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (47-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-70)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10875.87 Da
• Isoelectric Point: 10.2279

>T105713 WP_096920712.1 NZ_CP029487:c1417806-1417534 [Eubacterium maltosivorans]
MVEKKYTIVFSKRAEKDKKLIKAAGYEKKVREILQKLMIDPYYNPLDVLQGNLKGFYSKRINVQHRIVYEVLEEEKVVRI
ARMWTHYDKI

Nucleotide

• Length: 273 bp

>T105713 NZ_CP029487:c1417806-1417534 [Eubacterium maltosivorans]
ATGGTAGAGAAGAAGTACACTATTGTTTTTTCTAAACGAGCCGAGAAAGATAAAAAGTTAATAAAGGCTGCCGGATATGA
AAAGAAAGTTCGAGAAATTCTACAAAAACTGATGATTGATCCCTATTATAACCCCTTAGATGTTCTGCAAGGAAATTTAA
AGGGGTTTTATTCTAAGAGAATCAATGTTCAACATCGGATTGTTTATGAGGTACTGGAAGAGGAAAAAGTTGTCAGAATA
GCTCGTATGTGGACGCATTATGATAAGATTTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9514.58 Da
• Isoelectric Point: 3.8548

>AT105713 WP_096920711.1 NZ_CP029487:c1418054-1417800 [Eubacterium maltosivorans]
MSTVNVTSARKNLYQLVNDVNENSIPVTIVNNQGKNAVLLSEDDWKAIQETLYLNAIPGMVESILESRKEPVEECAVYDE
DEEW

Nucleotide

• Length: 255 bp

>AT105713 NZ_CP029487:c1418054-1417800 [Eubacterium maltosivorans]
ATGAGTACCGTAAATGTAACGAGCGCCAGGAAGAATTTATATCAGTTAGTGAATGATGTAAATGAAAACAGCATCCCGGT
TACCATCGTAAATAATCAGGGAAAAAATGCTGTATTATTATCTGAGGACGATTGGAAAGCAATTCAGGAAACACTCTACT
TAAATGCGATACCCGGTATGGTTGAATCTATTCTAGAATCCAGAAAAGAACCGGTTGAAGAATGTGCTGTATATGATGAG
GATGAAGAATGGTAG