Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 256500..257128 Replicon chromosome
Accession NZ_CP029479
Organism Phenylobacterium parvum strain HYN0004

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HYN04_RS01250 Protein ID WP_110449078.1
Coordinates 256500..256820 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HYN04_RS01255 Protein ID WP_110449079.1
Coordinates 256817..257128 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYN04_RS01240 252899..256216 + 3318 WP_162599502.1 DUF3427 domain-containing protein -
HYN04_RS01245 256352..256471 - 120 WP_110449077.1 hypothetical protein -
HYN04_RS01250 256500..256820 + 321 WP_110449078.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYN04_RS01255 256817..257128 + 312 WP_110449079.1 helix-turn-helix domain-containing protein Antitoxin
HYN04_RS01260 257142..258080 - 939 WP_110449080.1 bifunctional riboflavin kinase/FAD synthetase -
HYN04_RS01265 258083..258511 - 429 WP_110449081.1 MaoC family dehydratase -
HYN04_RS01270 258537..259433 - 897 WP_110449082.1 TIGR01459 family HAD-type hydrolase -
HYN04_RS01275 259523..260782 - 1260 WP_110449083.1 EAL domain-containing protein -
HYN04_RS01280 260911..261789 - 879 WP_110449084.1 3-hydroxybutyryl-CoA dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-99)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12389.36 Da        Isoelectric Point: 9.0802

>T105706 WP_110449078.1 NZ_CP029479:256500-256820 [Phenylobacterium parvum]
VWTVLYYNDRVRREIEEWPVGIYADFLRLVEWLEAEGLDLRMPHSRAMSGGLFELRCKGPEGIGRAFYCTQVGRELVILH
SIVKKSQATPDRDLKLARRRLKEVQS

Download         Length: 321 bp

>T105706 NZ_CP029479:256500-256820 [Phenylobacterium parvum]
GTGTGGACGGTTCTCTACTACAACGACCGCGTGAGGCGGGAGATCGAGGAATGGCCCGTCGGCATCTATGCCGACTTCCT
CCGCCTGGTGGAATGGCTGGAGGCGGAGGGCCTCGATCTCCGGATGCCCCACTCGCGGGCGATGAGCGGGGGATTGTTCG
AGCTTCGGTGCAAGGGGCCTGAAGGGATCGGTCGGGCGTTCTATTGCACGCAGGTCGGTCGCGAGCTGGTGATCCTGCAC
AGCATCGTGAAGAAGAGCCAGGCGACGCCCGACAGGGACCTTAAGCTGGCTCGCAGGCGTCTGAAGGAGGTGCAGTCATG
A

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11472.07 Da        Isoelectric Point: 10.0477

>AT105706 WP_110449079.1 NZ_CP029479:256817-257128 [Phenylobacterium parvum]
MSDPGFKPVRHDGNAALERAMQRPGFKEAWEAGADEYAALRSLLEARKQAGLTQEEIAIRMGTSKSAVSRLESSLRDPKH
SPTFETIRRYAKACGKRVEIQLV

Download         Length: 312 bp

>AT105706 NZ_CP029479:256817-257128 [Phenylobacterium parvum]
ATGAGCGATCCGGGTTTCAAGCCTGTCCGTCACGACGGAAATGCGGCCTTGGAAAGGGCGATGCAAAGGCCCGGGTTCAA
GGAGGCCTGGGAAGCCGGCGCCGATGAGTATGCGGCGCTGCGGTCCCTGCTTGAGGCGCGCAAACAGGCGGGCCTGACGC
AGGAGGAAATTGCGATCCGGATGGGGACTTCCAAGAGCGCCGTTTCGCGCCTGGAGAGCTCGCTGCGCGATCCCAAGCAC
TCGCCAACATTCGAGACAATCCGGCGTTATGCCAAGGCCTGCGGCAAGCGGGTGGAAATCCAGCTGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References