Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 361172..361356 Replicon chromosome
Accession NZ_CP029474
Organism Staphylococcus aureus strain USA 100 isolate 30-47

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag DKK89_RS01995 Protein ID WP_000482652.1
Coordinates 361249..361356 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 361172..361232 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DKK89_RS01970 356627..356794 - 168 Protein_363 hypothetical protein -
DKK89_RS01980 357025..358758 - 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
DKK89_RS01985 358783..360546 - 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
- 361172..361232 + 61 - - Antitoxin
DKK89_RS01995 361249..361356 - 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
DKK89_RS02000 361490..361876 - 387 WP_000779360.1 flippase GtxA -
DKK89_RS02005 362144..363286 + 1143 WP_001176863.1 glycerate kinase -
DKK89_RS02010 363346..364005 + 660 WP_000831298.1 membrane protein -
DKK89_RS02015 364187..365398 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
DKK89_RS02020 365521..365994 - 474 WP_000456486.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T105698 WP_000482652.1 NZ_CP029474:c361356-361249 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T105698 NZ_CP029474:c361356-361249 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT105698 NZ_CP029474:361172-361232 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References