Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 230959..231570 Replicon plasmid pSF25509b
Accession NZ_CP029452
Organism Sinorhizobium fredii CCBAU 25509

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag AOX55_RS21620 Protein ID WP_080577501.1
Coordinates 231289..231570 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag AOX55_RS21615 Protein ID WP_037395516.1
Coordinates 230959..231258 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOX55_RS21585 227801..228664 - 864 WP_037395524.1 Ku protein -
AOX55_RS21590 228922..229230 + 309 WP_037395522.1 DUF2934 domain-containing protein -
AOX55_RS21595 229296..229490 + 195 WP_037395520.1 cold-shock protein -
AOX55_RS21605 229804..230253 - 450 WP_037395518.1 helix-turn-helix transcriptional regulator -
AOX55_RS21615 230959..231258 - 300 WP_037395516.1 HigA family addiction module antidote protein Antitoxin
AOX55_RS21620 231289..231570 - 282 WP_080577501.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
AOX55_RS21625 231613..231813 + 201 WP_037395513.1 tautomerase family protein -
AOX55_RS21630 232229..232825 - 597 WP_037395511.1 mobile mystery protein B -
AOX55_RS21635 232822..233283 - 462 WP_037395509.1 mobile mystery protein A -
AOX55_RS21650 234777..234989 + 213 Protein_230 hypothetical protein -
AOX55_RS21655 235135..235573 - 439 Protein_231 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / katA 1..2210745 2210745


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-80)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10338.70 Da        Isoelectric Point: 9.8806

>T105678 WP_080577501.1 NZ_CP029452:c231570-231289 [Sinorhizobium fredii CCBAU 25509]
VIRSFKDAKTEAVARGKAPKGIPSDIVRSAVRKLTILNSAAARDDLRSPPGNRLEALKGDREGQHSNRINDQWRICFVWT
AAGIEDVEIVDYH

Download         Length: 282 bp

>T105678 NZ_CP029452:c231570-231289 [Sinorhizobium fredii CCBAU 25509]
GTGATCAGGTCATTTAAAGACGCCAAAACTGAAGCTGTTGCACGCGGCAAGGCCCCAAAAGGCATTCCTTCAGACATCGT
GAGGTCGGCCGTTCGTAAATTGACGATCCTGAACAGCGCAGCCGCTCGCGACGACCTGCGGTCCCCTCCGGGAAATCGAC
TTGAAGCCCTTAAGGGCGATAGAGAAGGCCAACATTCGAACCGGATCAATGATCAGTGGCGCATATGCTTCGTCTGGACA
GCTGCCGGTATCGAAGACGTCGAAATAGTTGACTATCATTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11326.20 Da        Isoelectric Point: 6.7273

>AT105678 WP_037395516.1 NZ_CP029452:c231258-230959 [Sinorhizobium fredii CCBAU 25509]
MTHILPPVHPGEILREEYLLPLNMSAGSLAKKLNVPRTRIERIAAEQTPITTDTALRLAKYFRTTPEFWMKMQTSFNLKT
EEIALHGELELIPEIDRAA

Download         Length: 300 bp

>AT105678 NZ_CP029452:c231258-230959 [Sinorhizobium fredii CCBAU 25509]
ATGACCCATATCCTTCCGCCGGTCCATCCGGGCGAAATCCTCCGCGAGGAGTACCTACTTCCTCTGAACATGAGCGCCGG
TTCACTGGCGAAAAAGCTCAATGTTCCTCGCACCCGCATCGAACGTATAGCGGCGGAGCAAACACCGATAACGACGGATA
CCGCTCTGCGCCTCGCCAAGTATTTCCGCACAACGCCGGAATTTTGGATGAAGATGCAGACCAGCTTCAACCTCAAGACA
GAGGAAATAGCGCTTCATGGCGAACTGGAGTTGATCCCGGAAATCGATAGAGCAGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References