Detailed information of TA system TA105671

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3705452..3706104
• Replicon: chromosome
• Accession: NZ_CP029449
• Organism: Serratia marcescens strain CAV1761

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DKC05_RS19615
• Protein ID: WP_038878669.1
• Coordinates: 3705760..3706104 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: DKC05_RS19610
• Protein ID: WP_038878665.1
• Coordinates: 3705452..3705754 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DKC05_RS19585	3700460..3701107	-	648	WP_047729966.1	DsbA family protein	-
DKC05_RS19590	3701176..3702060	-	885	WP_033635778.1	MBL fold metallo-hydrolase	-
DKC05_RS19595	3702169..3703077	+	909	WP_015378928.1	LysR family transcriptional regulator	-
DKC05_RS19600	3703105..3704028	-	924	WP_047729967.1	LysR family transcriptional regulator	-
DKC05_RS19605	3704162..3705424	+	1263	WP_038878662.1	diaminopimelate decarboxylase	-
DKC05_RS19610	3705452..3705754	-	303	WP_038878665.1	helix-turn-helix transcriptional regulator	Antitoxin
DKC05_RS19615	3705760..3706104	-	345	WP_038878669.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DKC05_RS19620	3706264..3707283	-	1020	WP_038878671.1	HTH-type transcriptional regulator GalR	-
DKC05_RS19625	3707504..3709762	+	2259	WP_038878674.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-
DKC05_RS28600	3709763..3709948	+	186	WP_038878678.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13367.40 Da
• Isoelectric Point: 10.6629

>T105671 WP_038878669.1 NZ_CP029449:c3706104-3705760 [Serratia marcescens]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T105671 NZ_CP029449:c3706104-3705760 [Serratia marcescens]
ATGTGGCAAGTGGTGACCGTCGAACGGTTCGACGACTGGTTTTTAGCGCTGAACAACGCCCAGCAAACAAGCATCCTGGC
GGCGATCTTCAAATTACAGACGTTCGGCCCGCAATTGGCACGGCCGCATGCCGATACGCTGCATTTTTCCGACGCGGTCC
GGCAGTTGAAGGAGCTGCGCATTCAACATCGCGGGCGCCCTTTCAGGGTATTTTTCGCCTTTGACCCACAGCGGCAAGCG
GTATTGCTGTGCGGCGGCGATAAAACCGGCGACCAACGCTTTTACCAGCGCATGTTGCCCATCGCCGCCATGGAGTTTTC
ACATTATCTGGCAACCCGGAGGTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT105671 WP_038878665.1 NZ_CP029449:c3705754-3705452 [Serratia marcescens]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT105671 NZ_CP029449:c3705754-3705452 [Serratia marcescens]
ATGGCCAAACCTTTATCCCAACTGATCGACAAGCTCGATCCCGCCGTCGTTGCCACAGCCAGGCAAAAAGCGGACAAGGA
AATTTTCGAGCTGCGGCTGGCGATGCTGAGGGAAGAGCTGGCGGTCTCTCAGGTTGAATTGGCGAAGCGGCTCGGCATCA
GCCAACCCTCCGTCGCCAATTTGGAAAAGCGCGGCAGCGAAATCAAACTGTCATCGCTCAAACGCTATATCGAGGCGATG
GGTGGCACGCTATCGCTGGATGTGCAATTGCCCAATGGCCAGCACCGCCGCATGACGCTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7