Detailed information of TA system TA105603

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2012963..2013482
• Replicon: chromosome
• Accession: NZ_CP029398
• Organism: Streptococcus suis strain HN105

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DF184_RS09950
• Protein ID: WP_109372056.1
• Coordinates: 2012963..2013220 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2S2F923
• Locus tag: DF184_RS09955
• Protein ID: WP_024383249.1
• Coordinates: 2013222..2013482 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DF184_RS09935	2009709..2011439	-	1731	WP_162564114.1	YfhO family protein	-
DF184_RS09940	2011642..2012514	-	873	WP_109372052.1	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA	-
DF184_RS09945	2012526..2012936	-	411	WP_109372054.1	hypothetical protein	-
DF184_RS09950	2012963..2013220	-	258	WP_109372056.1	Txe/YoeB family addiction module toxin	Toxin
DF184_RS09955	2013222..2013482	-	261	WP_024383249.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DF184_RS09960	2013997..2014452	-	456	WP_109372058.1	8-oxo-dGTP diphosphatase	-
DF184_RS09965	2014456..2014824	-	369	WP_024408018.1	hypothetical protein	-
DF184_RS09970	2014817..2015386	-	570	WP_024408019.1	ribonuclease M5	-
DF184_RS09975	2015370..2016152	-	783	WP_074414783.1	TatD family hydrolase	-
DF184_RS09980	2016259..2016396	-	138	WP_002939016.1	50S ribosomal protein L34	-
DF184_RS09985	2016564..2017559	-	996	WP_013730624.1	protein jag	-
DF184_RS09990	2017579..2018391	-	813	WP_024401396.1	YidC/Oxa1 family membrane protein insertase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10422.89 Da
• Isoelectric Point: 6.7254

>T105603 WP_109372056.1 NZ_CP029398:c2013220-2012963 [Streptococcus suis]
MGIHFTEDAWEDYLYWQDQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMVEADKLYILSL
KDHYQ

Nucleotide

• Length: 258 bp

>T105603 NZ_CP029398:c2013220-2012963 [Streptococcus suis]
ATGGGAATCCATTTCACAGAGGATGCTTGGGAAGACTATCTTTATTGGCAGGATCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAACGACACCCGTTTGAAGGTATTGCCAAGCCAGAACCTTTGAAGTATGATTATCAGG
GTGCCTGGTCGAGACGAATTGATGCGGAGAATCGCTTGATTTATATGGTAGAAGCAGATAAGCTGTATATCCTGTCGCTG
AAGGATCATTATCAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9950.34 Da
• Isoelectric Point: 5.7134

>AT105603 WP_024383249.1 NZ_CP029398:c2013482-2013222 [Streptococcus suis]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNTYLSQKVLRGMAQVKAGKTQER
NLIEAD

Nucleotide

• Length: 261 bp

>AT105603 NZ_CP029398:c2013482-2013222 [Streptococcus suis]
ATGGAAGCTATTGTATATTCCCATTTTCGAAACCACTTAAAGGACTATATGAAAAAGGTTAATGACGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTTTTGTCAAAGAGCGAGTGGGATAGTTTACAAGAAACCCTCG
CTGTTGCTCGGAACACTTATCTGTCTCAAAAAGTTTTGCGTGGTATGGCTCAAGTCAAAGCGGGGAAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAG

Structures

Antitoxin

• AlphaFold DB: A0A2S2F923