Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 743844..744619 Replicon chromosome
Accession NZ_CP029384
Organism Klebsiella pneumoniae subsp. pneumoniae strain SCKP020079

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag CLQ72_RS06680 Protein ID WP_004150910.1
Coordinates 744134..744619 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag CLQ72_RS06675 Protein ID WP_004150912.1
Coordinates 743844..744137 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CLQ72_RS06655 739052..739654 - 603 WP_062954968.1 short chain dehydrogenase -
CLQ72_RS06660 739752..740663 + 912 WP_004188550.1 LysR family transcriptional regulator -
CLQ72_RS06665 740664..741812 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
CLQ72_RS06670 741823..743193 - 1371 WP_004150913.1 cystathionine beta-synthase -
CLQ72_RS06675 743844..744137 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
CLQ72_RS06680 744134..744619 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
CLQ72_RS06685 745323..745916 + 594 WP_004188553.1 hypothetical protein -
CLQ72_RS06690 746013..746229 + 217 Protein_759 IS3 family transposase -
CLQ72_RS06695 746377..746562 + 186 WP_085666571.1 hypothetical protein -
CLQ72_RS06700 746504..746725 + 222 WP_004188555.1 hypothetical protein -
CLQ72_RS06705 746835..747707 + 873 WP_004188557.1 ParA family protein -
CLQ72_RS06710 747707..748090 + 384 WP_004150906.1 hypothetical protein -
CLQ72_RS06715 748083..749450 + 1368 WP_004150905.1 replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 746013..746165 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T105558 WP_004150910.1 NZ_CP029384:744134-744619 [Klebsiella pneumoniae subsp. pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T105558 NZ_CP029384:744134-744619 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT105558 WP_004150912.1 NZ_CP029384:743844-744137 [Klebsiella pneumoniae subsp. pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT105558 NZ_CP029384:743844-744137 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References