Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3866373..3866631 Replicon chromosome
Accession NZ_CP029369
Organism Escherichia coli strain WCHEC035148

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag DI496_RS21605 Protein ID WP_000809168.1
Coordinates 3866479..3866631 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3866373..3866430 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DI496_RS26320 3861427..3862203 + 777 WP_166666977.1 fimbria/pilus outer membrane usher protein -
DI496_RS26325 3862378..3862752 + 375 WP_021521651.1 hypothetical protein -
DI496_RS26100 3862765..3863723 + 959 Protein_3657 fimbrial family protein -
DI496_RS21595 3863762..3864661 - 900 WP_001300855.1 transcriptional activator NhaR -
DI496_RS21600 3864727..3865893 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 3866373..3866430 - 58 - - Antitoxin
DI496_RS21605 3866479..3866631 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
DI496_RS21610 3866735..3867865 - 1131 WP_001118464.1 molecular chaperone DnaJ -
DI496_RS21615 3867954..3869870 - 1917 WP_000516131.1 molecular chaperone DnaK -
DI496_RS21620 3870247..3870651 + 405 WP_000843559.1 DUF2541 family protein -
DI496_RS21625 3870677..3871390 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T105523 WP_000809168.1 NZ_CP029369:3866479-3866631 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T105523 NZ_CP029369:3866479-3866631 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT105523 NZ_CP029369:c3866430-3866373 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References