Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3784933..3785179 Replicon chromosome
Accession NZ_CP029327
Organism Escherichia coli strain A37

Toxin (Protein)


Gene name hokX Uniprot ID S1PD89
Locus tag AOY90_RS18310 Protein ID WP_000956458.1
Coordinates 3784933..3785085 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokX
Locus tag -
Coordinates 3785125..3785179 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AOY90_RS18295 3780760..3781668 - 909 WP_000372392.1 sulfate adenylyltransferase subunit CysD -
AOY90_RS18300 3781920..3782957 + 1038 WP_097738253.1 alkaline phosphatase isozyme conversion aminopeptidase -
AOY90_RS18305 3783074..3784738 - 1665 Protein_3564 CRISPR-associated helicase Cas3' -
AOY90_RS18310 3784933..3785085 - 153 WP_000956458.1 Hok/Gef family protein Toxin
- 3785125..3785179 + 55 - - Antitoxin
AOY90_RS18315 3785350..3786084 - 735 WP_000039862.1 phosphoadenosine phosphosulfate reductase -
AOY90_RS18320 3786158..3787870 - 1713 WP_001290708.1 assimilatory sulfite reductase (NADPH) hemoprotein subunit -
AOY90_RS18325 3787870..3789669 - 1800 WP_000211914.1 NADPH-dependent assimilatory sulfite reductase flavoprotein subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(5-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5558.77 Da        Isoelectric Point: 7.6757

>T105429 WP_000956458.1 NZ_CP029327:c3785085-3784933 [Escherichia coli]
MLTKYALVAIIVLCCTVLGFTLMVGDSLCELSIRERGMEFKAVLAYESKK

Download         Length: 153 bp

>T105429 NZ_CP029327:c3785085-3784933 [Escherichia coli]
ATGCTGACAAAATATGCCCTTGTGGCAATCATCGTACTGTGTTGTACAGTACTGGGATTCACGCTGATGGTAGGCGACTC
GTTGTGTGAGTTGAGTATCAGAGAACGTGGTATGGAGTTTAAGGCAGTTCTCGCTTACGAATCGAAGAAGTAG

Antitoxin


Download         Length: 55 bp

>AT105429 NZ_CP029327:3785125-3785179 [Escherichia coli]
GTTTGGGTTCGAACGTAAGCCTCAGGTTGATAGAAATATCGCCTGGGGCTTTTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TJ83

Antitoxin

Download structure file

References