Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4989535..4989956 Replicon chromosome
Accession NZ_CP029280
Organism Xanthomonas phaseoli pv. phaseoli strain Px100

Toxin (Protein)


Gene name higB Uniprot ID A0A3Q9Q4S9
Locus tag DGM85_RS21640 Protein ID WP_017156024.1
Coordinates 4989843..4989956 (-) Length 38 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DGM85_RS21635 Protein ID WP_017156025.1
Coordinates 4989535..4989825 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DGM85_RS21610 (DGM85_22710) 4984870..4985202 + 333 WP_003482333.1 hypothetical protein -
DGM85_RS21620 (DGM85_22720) 4985517..4987442 + 1926 WP_039574551.1 M61 family metallopeptidase -
DGM85_RS21625 4987510..4987689 + 180 WP_039574549.1 hypothetical protein -
DGM85_RS21630 (DGM85_22730) 4987792..4989180 - 1389 WP_039574546.1 type III secretion system effector XopQ -
DGM85_RS21635 (DGM85_22740) 4989535..4989825 - 291 WP_017156025.1 HigA family addiction module antitoxin Antitoxin
DGM85_RS21640 4989843..4989956 - 114 WP_017156024.1 hypothetical protein Toxin
DGM85_RS21645 (DGM85_22750) 4990221..4992728 - 2508 WP_046834789.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-94)


Sequences

Toxin        


Download         Length: 38 a.a.        Molecular weight: 4677.41 Da        Isoelectric Point: 9.1273

>T105391 WP_017156024.1 NZ_CP029280:c4989956-4989843 [Xanthomonas phaseoli pv. phaseoli]
MKGERRGQYRIRINDRWRICVRWMEGDVVQVEIIDYH

Download         Length: 114 bp

>T105391 NZ_CP029280:c4989956-4989843 [Xanthomonas phaseoli pv. phaseoli]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10387.09 Da        Isoelectric Point: 9.0188

>AT105391 WP_017156025.1 NZ_CP029280:c4989825-4989535 [Xanthomonas phaseoli pv. phaseoli]
MTVLPNIHPGAILLEEFLQPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTFERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT105391 NZ_CP029280:c4989825-4989535 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q9Q4S9

Antitoxin

Source ID Structure

References