Detailed information of TA system TA105386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 40270..40691
• Replicon: chromosome
• Accession: NZ_CP029277
• Organism: Xanthomonas phaseoli pv. phaseoli strain PR1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Q9Q4S9
• Locus tag: DGM93_RS00210
• Protein ID: WP_017156024.1
• Coordinates: 40578..40691 (-)
• Length: 38 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DGM93_RS00205
• Protein ID: WP_017156025.1
• Coordinates: 40270..40560 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DGM93_RS00180 (DGM93_00210)	35605..35937	+	333	WP_003482333.1	hypothetical protein	-
DGM93_RS00190 (DGM93_00220)	36252..38177	+	1926	WP_039574551.1	M61 family metallopeptidase	-
DGM93_RS00195	38245..38424	+	180	WP_039574549.1	hypothetical protein	-
DGM93_RS00200 (DGM93_00230)	38527..39915	-	1389	WP_039588131.1	type III secretion system effector XopQ	-
DGM93_RS00205 (DGM93_00240)	40270..40560	-	291	WP_017156025.1	HigA family addiction module antitoxin	Antitoxin
DGM93_RS00210	40578..40691	-	114	WP_017156024.1	hypothetical protein	Toxin
DGM93_RS00215 (DGM93_00250)	40956..43463	-	2508	WP_046834789.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	30531..71801	41270

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-94)

Sequences

Toxin

Protein

• Length: 38 a.a.
• Molecular weight: 4677.41 Da
• Isoelectric Point: 9.1273

>T105386 WP_017156024.1 NZ_CP029277:c40691-40578 [Xanthomonas phaseoli pv. phaseoli]
MKGERRGQYRIRINDRWRICVRWMEGDVVQVEIIDYH

Nucleotide

• Length: 114 bp

>T105386 NZ_CP029277:c40691-40578 [Xanthomonas phaseoli pv. phaseoli]
TTGAAGGGCGAGCGGCGCGGCCAGTACCGCATCCGGATCAACGATCGATGGCGCATCTGCGTCCGATGGATGGAAGGCGA
TGTGGTCCAGGTCGAAATCATCGATTACCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10387.09 Da
• Isoelectric Point: 9.0188

>AT105386 WP_017156025.1 NZ_CP029277:c40560-40270 [Xanthomonas phaseoli pv. phaseoli]
MTVLPNIHPGAILLEEFLQPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTFERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT105386 NZ_CP029277:c40560-40270 [Xanthomonas phaseoli pv. phaseoli]
ATGACGGTCCTGCCCAATATCCACCCTGGCGCAATTCTGCTTGAGGAGTTTCTCCAGCCTCTGGGCATCAGCCAGAACGC
ACTGGCACGCGCCACCGGCGTCCCGCCGCGCCGTATCAACGAAATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACTG
CCGTGCGTCTGGCCGCCGCGTTGGGAACCTTCGAGCGCTTCTGGCTTGGCCTGCAGGCCGACGACGAGCTGGAGCAGGCG
CATCGCGCGCTGGGCGACTTGCCGGCGCGGATCAAGCGGCTGGCGGCATGA

Structures

Toxin

• AlphaFold DB: A0A3Q9Q4S9