Detailed information of TA system TA105365

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-YefM
• Location: 2684112..2684627
• Replicon: chromosome
• Accession: NZ_CP029256
• Organism: Christensenella minuta strain DSM 22607

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: B1H56_RS12860
• Protein ID: WP_066521146.1
• Coordinates: 2684112..2684372 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A136Q997
• Locus tag: B1H56_RS12865
• Protein ID: WP_066521150.1
• Coordinates: 2684376..2684627 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
B1H56_RS12835	2679967..2681322	+	1356	WP_066651189.1	tail fiber domain-containing protein	-
B1H56_RS12840	2681319..2681588	+	270	WP_066523212.1	hypothetical protein	-
B1H56_RS14780	2681628..2682365	+	738	WP_066523724.1	peptidoglycan-binding protein	-
B1H56_RS12850	2682384..2682575	+	192	WP_066523721.1	hypothetical protein	-
B1H56_RS12855	2682859..2684115	-	1257	WP_066521143.1	tyrosine-type recombinase/integrase	-
B1H56_RS12860	2684112..2684372	-	261	WP_066521146.1	Txe/YoeB family addiction module toxin	Toxin
B1H56_RS12865	2684376..2684627	-	252	WP_066521150.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
B1H56_RS12870	2684689..2685228	-	540	WP_066521152.1	hypothetical protein	-
B1H56_RS12875	2685279..2685494	-	216	WP_066521154.1	hypothetical protein	-
B1H56_RS12880	2685531..2685884	-	354	WP_066521156.1	helix-turn-helix domain-containing protein	-
B1H56_RS12885	2686315..2686536	+	222	WP_066521164.1	hypothetical protein	-
B1H56_RS12890	2686536..2686787	+	252	WP_066521167.1	helix-turn-helix transcriptional regulator	-
B1H56_RS12895	2686797..2687129	+	333	WP_066521170.1	hypothetical protein	-
B1H56_RS12900	2687126..2687464	+	339	WP_066521173.1	hypothetical protein	-
B1H56_RS12905	2687558..2687743	+	186	WP_066521177.1	hypothetical protein	-
B1H56_RS12910	2687740..2687967	+	228	WP_066521179.1	hypothetical protein	-
B1H56_RS12915	2687960..2688208	+	249	WP_066521180.1	hypothetical protein	-
B1H56_RS12920	2688211..2688975	+	765	WP_121419011.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2657969..2721626	63657

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (7-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10098.75 Da
• Isoelectric Point: 10.0980

>T105365 WP_066521146.1 NZ_CP029256:c2684372-2684112 [Christensenella minuta]
MYDVQLTKRAFKDYAKLKQAGILKKAGELINILKQNPFQAPPPYEKLVGDLQGYYSRRINVQHRLVYSVDKDAQIVVIRS
MWTHYE

Nucleotide

• Length: 261 bp

>T105365 NZ_CP029256:c2684372-2684112 [Christensenella minuta]
ATGTACGATGTGCAATTGACAAAACGAGCCTTCAAGGATTATGCAAAATTGAAACAGGCGGGTATACTGAAAAAGGCCGG
AGAGCTAATTAATATTTTAAAGCAAAATCCCTTCCAGGCTCCCCCGCCTTACGAAAAGCTTGTAGGCGACTTGCAAGGCT
ATTACAGCCGTCGTATCAACGTACAGCATAGATTGGTCTACTCGGTGGATAAGGATGCTCAAATCGTCGTTATACGCAGC
ATGTGGACGCATTACGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9436.49 Da
• Isoelectric Point: 3.9541

>AT105365 WP_066521150.1 NZ_CP029256:c2684627-2684376 [Christensenella minuta]
MEAINITKARQNLYKLVKDTNESHAPIQILGKDGNAVLLSEDDWRSIQETLYLYSVPGLVESIKESENEPVEEMVSADDL
DWE

Nucleotide

• Length: 252 bp

>AT105365 NZ_CP029256:c2684627-2684376 [Christensenella minuta]
ATGGAGGCGATCAATATTACAAAAGCACGGCAGAATTTATATAAGCTTGTGAAAGATACCAACGAATCCCACGCCCCAAT
CCAGATACTCGGCAAGGATGGAAACGCTGTTCTTCTCTCCGAGGACGATTGGAGGTCTATACAGGAGACTTTATACCTGT
ATTCTGTTCCTGGCCTTGTAGAGAGCATCAAGGAGAGCGAGAACGAGCCTGTAGAAGAAATGGTAAGCGCTGATGACCTC
GATTGGGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A136Q997