Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1147588..1148183 Replicon chromosome
Accession NZ_CP029255
Organism Flavobacterium crocinum strain HYN0056

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag HYN56_RS05300 Protein ID WP_109191229.1
Coordinates 1147902..1148183 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HYN56_RS05295 Protein ID WP_109191228.1
Coordinates 1147588..1147890 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYN56_RS05270 1142947..1144071 + 1125 WP_109191223.1 glycosyltransferase -
HYN56_RS05275 1144136..1145119 + 984 WP_109191224.1 SDR family oxidoreductase -
HYN56_RS05280 1145142..1145909 + 768 WP_109191225.1 glycosyltransferase -
HYN56_RS05285 1145939..1146235 - 297 WP_109191226.1 ORF6N domain-containing protein -
HYN56_RS05290 1146272..1147588 - 1317 WP_109191227.1 phenylacetate--CoA ligase family protein -
HYN56_RS05295 1147588..1147890 - 303 WP_109191228.1 HigA family addiction module antidote protein Antitoxin
HYN56_RS05300 1147902..1148183 - 282 WP_109191229.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HYN56_RS05305 1148280..1149554 + 1275 WP_109191230.1 phosphoribosylamine--glycine ligase -
HYN56_RS05310 1149597..1149827 - 231 WP_109191231.1 uracil phosphoribosyltransferase -
HYN56_RS05315 1149969..1150898 + 930 WP_109191232.1 hypothetical protein -
HYN56_RS05320 1150893..1151546 - 654 WP_109191233.1 uracil phosphoribosyltransferase -
HYN56_RS05325 1151658..1152263 + 606 WP_109191234.1 DUF4254 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-95)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10898.55 Da        Isoelectric Point: 10.4688

>T105363 WP_109191229.1 NZ_CP029255:c1148183-1147902 [Flavobacterium crocinum]
MIISFGSKETEKIWNGIVVKKPSIEIQQIGRRKLRMLNNSQNINDLKIPPSNRLEKLSGNLKDFYSIRINNQWRIIFAWE
NGNASNVEIIDYH

Download         Length: 282 bp

>T105363 NZ_CP029255:c1148183-1147902 [Flavobacterium crocinum]
ATGATAATCTCATTTGGATCGAAAGAAACTGAAAAAATTTGGAATGGTATTGTGGTTAAAAAACCTTCAATTGAGATTCA
ACAAATTGGAAGAAGAAAACTCAGAATGCTGAACAATTCTCAAAATATCAACGATTTAAAAATTCCACCTTCCAATCGTT
TAGAAAAACTAAGTGGAAACTTAAAAGATTTTTACAGCATTAGGATCAACAATCAATGGAGAATAATTTTTGCTTGGGAA
AATGGGAATGCTTCCAATGTTGAAATTATTGATTATCACTAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11667.38 Da        Isoelectric Point: 7.0166

>AT105363 WP_109191228.1 NZ_CP029255:c1147890-1147588 [Flavobacterium crocinum]
MEKLKNIHPGEILSEEFLIPLNITPYRLSKDLKIPQTRISEIIKGNRRITADTALRLSKYFGNSAKFWLGLQDDFDIEEE
ESNKSQELKSIKRYDLKEAV

Download         Length: 303 bp

>AT105363 NZ_CP029255:c1147890-1147588 [Flavobacterium crocinum]
ATGGAAAAATTAAAAAATATACATCCCGGCGAAATTTTATCAGAAGAATTTTTAATTCCTCTAAATATTACACCTTATCG
TTTATCTAAAGATTTAAAAATTCCGCAGACAAGAATTTCTGAAATTATTAAAGGGAACCGCAGAATAACTGCTGATACTG
CTTTGCGATTAAGCAAGTATTTTGGGAATTCTGCTAAATTTTGGCTCGGACTTCAAGACGATTTCGATATTGAAGAAGAA
GAATCGAATAAAAGTCAGGAACTTAAATCAATTAAACGTTACGACTTAAAAGAAGCTGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References