Detailed information of TA system TA105361

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA(toxin)
• Location: 159841..161071
• Replicon: chromosome
• Accession: NZ_CP029255
• Organism: Flavobacterium crocinum strain HYN0056

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: HYN56_RS00825
• Protein ID: WP_109190453.1
• Coordinates: 159841..160764 (-)
• Length: 308 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: -
• Locus tag: HYN56_RS00830
• Protein ID: WP_109190454.1
• Coordinates: 160757..161071 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HYN56_RS00810	155555..158173	+	2619	WP_109190451.1	TonB-dependent receptor	-
HYN56_RS00815	158178..159017	+	840	WP_167398258.1	DUF4249 domain-containing protein	-
HYN56_RS00820	159230..159829	-	600	WP_109194690.1	hypothetical protein	-
HYN56_RS00825	159841..160764	-	924	WP_109190453.1	HipA domain-containing protein	Toxin
HYN56_RS00830	160757..161071	-	315	WP_109190454.1	HipA N-terminal domain-containing protein	Antitoxin
HYN56_RS00835	161075..161284	-	210	WP_109190455.1	helix-turn-helix domain-containing protein	-
HYN56_RS00840	161503..163305	-	1803	WP_109190456.1	beta-glucuronidase	-
HYN56_RS00845	164221..165639	-	1419	WP_109190457.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (52-278)

Antitoxin

• HipA, N-terminal subdomain 1 (5-98)

Sequences

Toxin

Protein

• Length: 308 a.a.
• Molecular weight: 35558.18 Da
• Isoelectric Point: 9.4604

>T105361 WP_109190453.1 NZ_CP029255:c160764-159841 [Flavobacterium crocinum]
MNRCPITYELCGDELYSIKGLKLLSPKLTSFHNLPFSASEQRQEAVNRASKLSIQGVQPKLSAVLSIKKQQFEIVDQFGN
FIIKPQSDIFPELPENEDLTMRMAKVYGIEVPLHGLVYSKDHSKSYFIKRFDRYSKGRKFATEDFAQLTGSSRDTKYNFT
MEKIVKVLDDFCTFPSIEKAELFKRVLFCFVTGNEDMHLKNFSLITKSGKTTLAPAYDFLNSSIAIKNPQEEMALKLKGK
KSNFKATDLIDYFAKERLGLSDKVIDQIMKRMFENAEKWNDLIEISFLSEDMKEKYFKLLRERIGRF

Nucleotide

• Length: 924 bp

>T105361 NZ_CP029255:c160764-159841 [Flavobacterium crocinum]
ATGAATAGATGTCCCATCACATATGAACTGTGTGGAGATGAACTATACAGTATTAAAGGATTAAAACTGCTGTCTCCTAA
ATTAACTTCTTTTCATAATCTTCCTTTTTCTGCTTCTGAACAAAGACAAGAAGCGGTAAATAGAGCTAGTAAATTATCTA
TTCAAGGGGTTCAGCCTAAGTTAAGTGCTGTTTTATCAATTAAAAAACAACAATTCGAAATCGTAGATCAGTTTGGCAAT
TTCATTATAAAACCTCAAAGCGATATTTTTCCTGAGTTGCCCGAAAATGAAGACCTTACCATGCGAATGGCAAAAGTCTA
CGGAATCGAAGTACCGCTTCATGGATTGGTTTATTCTAAAGACCATTCAAAATCGTATTTTATAAAAAGATTTGATCGTT
ACAGTAAAGGAAGAAAATTTGCTACAGAAGATTTTGCACAGTTAACAGGAAGTTCCAGAGATACAAAATATAATTTTACG
ATGGAGAAAATTGTAAAAGTTTTGGATGATTTCTGCACATTTCCTTCCATTGAAAAAGCAGAACTTTTTAAAAGAGTATT
ATTTTGTTTTGTGACGGGCAATGAAGATATGCACCTGAAAAATTTTTCACTGATTACAAAATCAGGAAAAACAACTTTAG
CACCTGCTTATGATTTTCTAAACTCTTCTATTGCGATAAAAAATCCTCAGGAAGAAATGGCTCTAAAATTAAAAGGCAAA
AAAAGTAATTTTAAAGCCACTGATTTGATTGATTATTTTGCCAAAGAAAGATTAGGACTTAGTGATAAAGTTATCGATCA
GATCATGAAGAGAATGTTTGAAAATGCAGAGAAATGGAACGATCTGATTGAGATTTCATTTTTATCTGAAGATATGAAAG
AGAAGTATTTTAAATTGCTGAGAGAACGCATTGGAAGATTTTAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11638.19 Da
• Isoelectric Point: 4.3128

>AT105361 WP_109190454.1 NZ_CP029255:c161071-160757 [Flavobacterium crocinum]
MRKAIVYVHGVRAGELVEEENGSYLFEYDNDYSAEPVSLTMPVAHKKYSFSNFPPFFEGLLPEGIMLEGLLKINKIDTKD
YFSQLIATGSDLVGAVTVKEVDNE

Nucleotide

• Length: 315 bp

>AT105361 NZ_CP029255:c161071-160757 [Flavobacterium crocinum]
ATGAGAAAAGCAATTGTTTATGTACATGGTGTAAGAGCTGGCGAGCTTGTAGAAGAAGAAAATGGCAGCTATCTATTTGA
GTATGATAATGATTATTCAGCAGAACCAGTTTCACTTACAATGCCAGTTGCTCATAAAAAATATTCTTTCTCAAATTTTC
CACCATTTTTTGAAGGATTACTCCCAGAAGGAATAATGCTGGAGGGACTTTTAAAAATAAATAAAATAGACACAAAAGAT
TATTTTTCGCAGCTTATTGCAACGGGAAGTGATTTAGTTGGAGCGGTAACGGTTAAAGAAGTTGATAATGAATAG