Detailed information of TA system TA105200

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 2019314..2019494
• Replicon: chromosome
• Accession: NZ_CP029198
• Organism: Staphylococcus aureus strain aureus

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: FORC090_RS10070
• Protein ID: WP_001801861.1
• Coordinates: 2019314..2019409 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	2019437..2019494 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC090_RS10040	2014477..2015127	+	651	WP_001795210.1	excalibur calcium-binding domain-containing protein	-
FORC090_RS10045	2015208..2016203	+	996	WP_000070642.1	DUF4352 domain-containing protein	-
FORC090_RS10050	2016278..2016904	+	627	WP_000669024.1	hypothetical protein	-
FORC090_RS10055	2016945..2017286	+	342	WP_000627540.1	DUF3969 family protein	-
FORC090_RS10060	2017387..2017959	+	573	WP_000414216.1	hypothetical protein	-
FORC090_RS10065	2018157..2019169	-	1013	Protein_1933	IS3 family transposase	-
FORC090_RS10070	2019314..2019409	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	2019437..2019494	-	58	-	-	Antitoxin
FORC090_RS10075	2019532..2019633	+	102	WP_001792025.1	hypothetical protein	-
FORC090_RS10080	2019611..2019772	-	162	Protein_1936	transposase	-
FORC090_RS10085	2019763..2020257	-	495	Protein_1937	transposase	-
FORC090_RS10090	2020715..2021350	-	636	Protein_1938	restriction endonuclease subunit S	-
FORC090_RS10095	2021343..2022899	-	1557	WP_000028669.1	type I restriction-modification system subunit M	-
FORC090_RS10100	2023063..2023197	-	135	WP_001791797.1	hypothetical protein	-
FORC090_RS10105	2023260..2023979	-	720	WP_001038752.1	serine protease SplF	-
FORC090_RS10110	2024081..2024188	+	108	WP_011447030.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA / selk	2013719..2067803	54084

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-121)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T105200 WP_001801861.1 NZ_CP029198:2019314-2019409 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T105200 NZ_CP029198:2019314-2019409 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT105200 NZ_CP029198:c2019494-2019437 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin