Detailed information of TA system TA105197

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1682368..1682947
• Replicon: chromosome
• Accession: NZ_CP029198
• Organism: Staphylococcus aureus strain aureus

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: FORC090_RS08370
• Protein ID: WP_001025401.1
• Coordinates: 1682702..1682947 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1682368..1682733 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FORC090_RS08330	1679112..1679669	-	558	WP_000645045.1	DUF2815 family protein	-
FORC090_RS08335	1679695..1680861	-	1167	WP_000762525.1	DUF2800 domain-containing protein	-
FORC090_RS08340	1680858..1681220	-	363	WP_000279445.1	hypothetical protein	-
FORC090_RS08345	1681235..1681558	-	324	WP_000174995.1	hypothetical protein	-
FORC090_RS08350	1681637..1681798	-	162	WP_015986189.1	DUF1270 family protein	-
FORC090_RS08355	1681810..1682073	-	264	WP_044426023.1	helix-turn-helix domain-containing protein	-
FORC090_RS08360	1682098..1682313	-	216	WP_001097552.1	hypothetical protein	-
FORC090_RS08365	1682368..1682733	+	366	WP_001128433.1	hypothetical protein	Antitoxin
FORC090_RS08370	1682702..1682947	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
FORC090_RS08375	1683003..1683212	+	210	WP_000642492.1	hypothetical protein	-
FORC090_RS08380	1683202..1683345	-	144	WP_000939498.1	hypothetical protein	-
FORC090_RS08385	1683360..1683803	-	444	WP_044414793.1	hypothetical protein	-
FORC090_RS08390	1683827..1684048	-	222	WP_031887876.1	DUF739 family protein	-
FORC090_RS08395	1684209..1684979	+	771	WP_031887877.1	helix-turn-helix domain-containing protein	-
FORC090_RS15515	1684991..1685137	+	147	WP_001049401.1	hypothetical protein	-
FORC090_RS08400	1685134..1685319	+	186	WP_000109189.1	hypothetical protein	-
FORC090_RS08405	1685389..1685556	+	168	WP_000705241.1	hypothetical protein	-
FORC090_RS08410	1685696..1686400	+	705	WP_000440838.1	type II toxin-antitoxin system PemK/MazF family toxin	-
FORC090_RS08415	1686611..1687816	+	1206	WP_031766111.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1643023..1700568	57545

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T105197 WP_001025401.1 NZ_CP029198:c1682947-1682702 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T105197 NZ_CP029198:c1682947-1682702 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT105197 NZ_CP029198:1682368-1682733 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin