Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4710678..4711210 Replicon chromosome
Accession NZ_CP029190
Organism Streptomyces venezuelae strain ATCC 21782

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag DEJ50_RS21170 Protein ID WP_150209528.1
Coordinates 4710956..4711210 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag DEJ50_RS21165 Protein ID WP_150209527.1
Coordinates 4710678..4710959 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEJ50_RS21140 4706200..4707378 - 1179 WP_150209523.1 ImmA/IrrE family metallo-endopeptidase -
DEJ50_RS21145 4707400..4708209 - 810 WP_150209524.1 hypothetical protein -
DEJ50_RS21150 4708458..4708913 - 456 WP_150212264.1 hypothetical protein -
DEJ50_RS21155 4709157..4709888 - 732 WP_150209525.1 HEAT repeat domain-containing protein -
DEJ50_RS21160 4709885..4710271 - 387 WP_150209526.1 hypothetical protein -
DEJ50_RS21165 4710678..4710959 + 282 WP_150209527.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DEJ50_RS21170 4710956..4711210 + 255 WP_150209528.1 Txe/YoeB family addiction module toxin Toxin
DEJ50_RS21175 4711338..4711591 - 254 Protein_4128 type II toxin-antitoxin system RelE/ParE family toxin -
DEJ50_RS21180 4711584..4711781 - 198 WP_150209529.1 prevent-host-death protein -
DEJ50_RS21185 4711895..4712710 - 816 WP_150209530.1 phytanoyl-CoA dioxygenase family protein -
DEJ50_RS21190 4712756..4713481 - 726 WP_190344599.1 LmbU family transcriptional regulator -
DEJ50_RS21195 4713568..4714890 - 1323 WP_150209531.1 UDP-glucose/GDP-mannose dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-65)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10071.63 Da        Isoelectric Point: 9.3746

>T105192 WP_150209528.1 NZ_CP029190:4710956-4711210 [Streptomyces venezuelae]
VRLVFEGQGWDDYTSWLKNDRKMLARINKLIEDVRRDPFTGIGKPEPLKYHLPGAWLRRIDDEQRLVYLVTDKEIVILAA
RYHY

Download         Length: 255 bp

>T105192 NZ_CP029190:4710956-4711210 [Streptomyces venezuelae]
GTGAGGCTTGTCTTCGAGGGTCAGGGCTGGGATGACTACACATCCTGGCTCAAGAACGACCGCAAGATGCTCGCCCGGAT
CAACAAGCTGATCGAGGACGTCAGGCGCGACCCGTTCACCGGCATCGGTAAGCCCGAGCCGCTGAAGTACCACCTGCCTG
GGGCATGGTTGCGGCGGATCGACGACGAACAACGTCTCGTCTATCTGGTGACGGACAAGGAGATCGTCATCCTCGCGGCC
AGGTACCACTACTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 9971.24 Da        Isoelectric Point: 6.2218

>AT105192 WP_150209527.1 NZ_CP029190:4710678-4710959 [Streptomyces venezuelae]
MSITASDARKALFPLIKKVNENHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPANARRLLKAYENALAHINVSEREL
IDPDSADAGAGAA

Download         Length: 282 bp

>AT105192 NZ_CP029190:4710678-4710959 [Streptomyces venezuelae]
ATGTCGATAACCGCGAGCGACGCCCGCAAGGCTCTCTTTCCGCTGATCAAGAAGGTCAACGAAAATCACGAGGCCATCGA
GATCGTCTCCAAGCACGGCAATGCCGTACTCGTCTCGGCCGAGGACTATGCGGCGCTGCGCGAGGGCTCGTACCTGCTGC
GCTCCCCGGCGAATGCGCGCCGCCTGCTCAAGGCGTACGAGAACGCCCTGGCGCACATCAACGTGTCGGAGCGGGAGCTG
ATCGATCCGGATTCGGCGGACGCGGGTGCGGGTGCCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References