Detailed information of TA system TA105187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 4795744..4796282
• Replicon: chromosome
• Accession: NZ_CP029189
• Organism: Streptomyces venezuelae strain ATCC 21018

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: DEJ51_RS21475
• Protein ID: WP_150259041.1
• Coordinates: 4796028..4796282 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: DEJ51_RS21470
• Protein ID: WP_150259040.1
• Coordinates: 4795744..4796031 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEJ51_RS21455	4791722..4792858	+	1137	WP_150259037.1	Fic family protein	-
DEJ51_RS34615	4792919..4793062	+	144	WP_190620541.1	hypothetical protein	-
DEJ51_RS21460	4793474..4795114	+	1641	WP_150259038.1	hypothetical protein	-
DEJ51_RS21465	4795129..4795584	+	456	WP_150259039.1	hypothetical protein	-
DEJ51_RS21470	4795744..4796031	+	288	WP_150259040.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DEJ51_RS21475	4796028..4796282	+	255	WP_150259041.1	Txe/YoeB family addiction module toxin	Toxin
DEJ51_RS21480	4796435..4796623	-	189	WP_150259042.1	hypothetical protein	-
DEJ51_RS21485	4797171..4798583	-	1413	WP_190620969.1	hypothetical protein	-
DEJ51_RS21490	4799138..4799905	+	768	Protein_4209	ATP-dependent helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-65)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10019.42 Da
• Isoelectric Point: 6.7267

>T105187 WP_150259041.1 NZ_CP029189:4796028-4796282 [Streptomyces venezuelae]
VRLVFEDQGGEDYTSWLKDDRKMLARIDKFIEDVRRDPFSGIGKPEPLKYHLPGAWSRRIDDEHRLVYLVTDKEIIVLAA
RYHY

Nucleotide

• Length: 255 bp

>T105187 NZ_CP029189:4796028-4796282 [Streptomyces venezuelae]
GTGAGGCTTGTCTTTGAGGATCAGGGCGGGGAGGACTACACGTCCTGGCTCAAGGACGACCGCAAGATGCTCGCCCGGAT
CGACAAGTTCATCGAGGACGTCAGACGTGACCCGTTCTCAGGGATCGGCAAGCCCGAACCTCTGAAGTACCACCTGCCCG
GCGCGTGGTCGCGGCGGATCGACGACGAGCACCGCCTCGTCTACCTGGTCACGGACAAGGAGATCATCGTCCTTGCGGCT
CGGTATCACTACTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10264.52 Da
• Isoelectric Point: 4.8668

>AT105187 WP_150259040.1 NZ_CP029189:4795744-4796031 [Streptomyces venezuelae]
MSITASEARRGLFSLIKKVNENHEAIEIVSKHGNAVLVSAEDYAALREGSYLLRSPVNARRLLKAYENALANINVLEREL
IDPDSADEGEGAGAA

Nucleotide

• Length: 288 bp

>AT105187 NZ_CP029189:4795744-4796031 [Streptomyces venezuelae]
ATGTCCATAACCGCCAGCGAAGCTCGCAGGGGACTCTTTTCGCTGATCAAGAAGGTCAACGAGAACCACGAGGCCATCGA
GATCGTCTCGAAGCACGGCAACGCCGTACTCGTCTCAGCCGAGGACTACGCAGCCCTGCGCGAAGGGTCGTACCTGCTGC
GCTCTCCGGTGAACGCGCGCCGGCTGCTCAAGGCGTACGAGAACGCCCTGGCGAACATCAACGTGTTGGAGCGCGAGCTG
ATCGATCCGGACTCGGCGGACGAGGGTGAGGGTGCGGGTGCCGCGTGA