Detailed information of TA system TA105140

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprG3-SprA2AS/-
• Location: 2290704..2290902
• Replicon: chromosome
• Accession: NZ_CP029172
• Organism: Staphylococcus aureus strain PTDrAP2

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: DD562_RS11775
• Protein ID: WP_001802298.1
• Coordinates: 2290798..2290902 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2290704..2290742 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD562_RS11755	2286824..2287489	-	666	WP_001024099.1	SDR family oxidoreductase	-
DD562_RS11760	2287641..2287961	+	321	WP_109028251.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
DD562_RS11765	2287963..2288943	+	981	WP_000019735.1	CDF family zinc efflux transporter CzrB	-
DD562_RS11770	2289209..2290300	+	1092	WP_000495673.1	hypothetical protein	-
-	2290704..2290742	+	39	-	-	Antitoxin
DD562_RS11775	2290798..2290902	-	105	WP_001802298.1	hypothetical protein	Toxin
DD562_RS11790	2291582..2291740	+	159	WP_001792784.1	hypothetical protein	-
DD562_RS11800	2292398..2293255	-	858	WP_000370942.1	Cof-type HAD-IIB family hydrolase	-
DD562_RS11805	2293323..2294105	-	783	WP_000908191.1	ABC transporter ATP-binding protein	-
DD562_RS11810	2294395..2295003	-	609	WP_109028252.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T105140 WP_001802298.1 NZ_CP029172:c2290902-2290798 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T105140 NZ_CP029172:c2290902-2290798 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 39 bp

>AT105140 NZ_CP029172:2290704-2290742 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin