Detailed information of TA system TA105135

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1147166..1147415
• Replicon: chromosome
• Accession: NZ_CP029172
• Organism: Staphylococcus aureus strain PTDrAP2

Toxin (Protein)

• Gene name: SprG2
• Uniprot ID: -
• Locus tag: DD562_RS05935
• Protein ID: WP_000623369.1
• Coordinates: 1147166..1147273 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	1147268..1147415 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD562_RS05910	1143840..1144409	-	570	WP_000287265.1	competence protein ComK	-
DD562_RS05915	1144619..1144837	+	219	WP_000876826.1	IDEAL domain-containing protein	-
DD562_RS05920	1144918..1145904	-	987	WP_000668814.1	lipoate--protein ligase	-
DD562_RS05925	1146103..1146279	+	177	WP_000214898.1	YkvS family protein	-
DD562_RS05930	1146294..1146896	+	603	WP_001033867.1	CPBP family intramembrane metalloprotease	-
DD562_RS05935	1147166..1147273	+	108	WP_000623369.1	putative holin-like toxin	Toxin
-	1147268..1147415	-	148	-	-	Antitoxin
DD562_RS05940	1147908..1148192	+	285	WP_000790905.1	lactococcin 972 family bacteriocin	-
DD562_RS05945	1148236..1150200	+	1965	WP_000870811.1	bacteriocin-associated integral membrane family protein	-
DD562_RS05950	1150203..1150523	+	321	WP_000668623.1	YxeA family protein	-
DD562_RS05955	1150520..1151161	+	642	WP_000571192.1	ABC transporter ATP-binding protein	-
DD562_RS05960	1151249..1151539	-	291	WP_001796515.1	hypothetical protein	-
DD562_RS05965	1151629..1151817	+	189	WP_157958947.1	poly(glycerol-phosphate) alpha-glucosyltransferase	-
DD562_RS05970	1151906..1152262	-	357	WP_000766009.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (3-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3801.69 Da
• Isoelectric Point: 10.8004

>T105135 WP_000623369.1 NZ_CP029172:1147166-1147273 [Staphylococcus aureus]
VISIANALHLMLSFGMFIVTFIGVVVAIINLNNKK

Nucleotide

• Length: 108 bp

>T105135 NZ_CP029172:1147166-1147273 [Staphylococcus aureus]
GTGATATCTATTGCAAATGCATTACATTTAATGTTAAGTTTCGGTATGTTTATCGTCACTTTCATTGGTGTAGTAGTCGC
AATAATTAATTTAAACAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 148 bp

>AT105135 NZ_CP029172:c1147415-1147268 [Staphylococcus aureus]
CAATTAAATAAAAGATATGTTACTATAAAAATGTAAAAAGACGACATGCAGTAACATGTCGCCTAATGAGCCCGTTAAAA
AGACGGTGACTAAATGAGATTTGCTTTAACCATCATTCGTTGTCAAAGTTTTGAAATGATGGTTATTT

Structures

Antitoxin