Detailed information of TA system TA105132

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 420131..420388
• Replicon: chromosome
• Accession: NZ_CP029172
• Organism: Staphylococcus aureus strain PTDrAP2

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: DD562_RS02085
• Protein ID: WP_109028190.1
• Coordinates: 420131..420376 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	420346..420388 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD562_RS02040	415444..416058	+	615	WP_000191466.1	hypothetical protein	-
DD562_RS02045	416431..417015	-	585	WP_000825948.1	hypothetical protein	-
DD562_RS02050	417033..417494	-	462	WP_109028188.1	toxin	-
DD562_RS02055	417507..417821	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DD562_RS02060	417973..418209	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DD562_RS02065	418223..418999	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DD562_RS14950	419028..419177	+	150	WP_000771849.1	hypothetical protein	-
DD562_RS02070	419218..419430	-	213	WP_000362644.1	hypothetical protein	-
DD562_RS02075	419500..419697	+	198	WP_109028189.1	hypothetical protein	-
DD562_RS02080	419684..420064	-	381	WP_000773060.1	DUF2513 domain-containing protein	-
DD562_RS02085	420131..420376	+	246	WP_109028190.1	DUF2829 domain-containing protein	Toxin
-	420346..420388	-	43	-	-	Antitoxin
DD562_RS02090	420435..420761	+	327	WP_001588858.1	hypothetical protein	-
DD562_RS02095	420776..420919	+	144	WP_000939502.1	hypothetical protein	-
DD562_RS02100	420909..421118	-	210	WP_000642492.1	hypothetical protein	-
DD562_RS02105	421174..421389	+	216	WP_001097552.1	hypothetical protein	-
DD562_RS02110	421414..421677	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
DD562_RS02115	421690..421851	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
DD562_RS02120	421930..422253	+	324	WP_000174994.1	hypothetical protein	-
DD562_RS02125	422268..422630	+	363	WP_031808061.1	hypothetical protein	-
DD562_RS02130	422627..423793	+	1167	WP_109028191.1	DUF2800 domain-containing protein	-
DD562_RS02135	423820..424374	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	414113..459693	45580

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9480.77 Da
• Isoelectric Point: 5.7783

>T105132 WP_109028190.1 NZ_CP029172:420131-420376 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPIRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T105132 NZ_CP029172:420131-420376 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAATTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 43 bp

>AT105132 NZ_CP029172:c420388-420346 [Staphylococcus aureus]
TTTATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTA

Structures

Antitoxin