Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2629419..2629942 Replicon chromosome
Accession NZ_CP029166
Organism Staphylococcus aureus strain SVH7513

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag DD555_RS13965 Protein ID WP_000074048.1
Coordinates 2629419..2629685 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag DD555_RS13970 Protein ID WP_084927543.1
Coordinates 2629685..2629942 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD555_RS13940 2624977..2625753 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
DD555_RS13945 2625746..2626408 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
DD555_RS13950 2626529..2627701 - 1173 WP_000195429.1 IS256-like element IS256 family transposase -
DD555_RS13960 2627988..2629064 - 1077 WP_001076686.1 M42 family metallopeptidase -
DD555_RS13965 2629419..2629685 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
DD555_RS13970 2629685..2629942 - 258 WP_084927543.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DD555_RS13980 2630301..2630756 + 456 WP_000732082.1 DUF1307 domain-containing protein -
DD555_RS13985 2630924..2632501 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
DD555_RS13990 2632696..2633445 + 750 WP_000072443.1 hypothetical protein -
DD555_RS13995 2633669..2634862 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2626529..2627701 1172


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T105129 WP_000074048.1 NZ_CP029166:c2629685-2629419 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T105129 NZ_CP029166:c2629685-2629419 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9760.71 Da        Isoelectric Point: 4.1353

>AT105129 WP_084927543.1 NZ_CP029166:c2629942-2629685 [Staphylococcus aureus]
MVITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT105129 NZ_CP029166:c2629942-2629685 [Staphylococcus aureus]
ATGGTTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References