Detailed information of TA system TA105117

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2127608..2127915
• Replicon: chromosome
• Accession: NZ_CP029166
• Organism: Staphylococcus aureus strain SVH7513

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DD555_RS11125
• Protein ID: WP_011447039.1
• Coordinates: 2127739..2127915 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2127608..2127747 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD555_RS11065	2123175..2123354	+	180	WP_000669791.1	hypothetical protein	-
DD555_RS11075	2123665..2123925	+	261	WP_001791826.1	hypothetical protein	-
DD555_RS11080	2123978..2124328	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DD555_RS11085	2124838..2125173	-	336	Protein_2035	SH3 domain-containing protein	-
DD555_RS11105	2125824..2126315	-	492	WP_000920038.1	staphylokinase	-
DD555_RS11110	2126506..2127261	-	756	WP_000861038.1	CHAP domain-containing protein	-
DD555_RS11115	2127273..2127527	-	255	WP_000611508.1	phage holin	-
DD555_RS11120	2127579..2127686	+	108	WP_031762631.1	hypothetical protein	-
-	2127608..2127747	+	140	NuclAT_0	-	Antitoxin
-	2127608..2127747	+	140	NuclAT_0	-	Antitoxin
-	2127608..2127747	+	140	NuclAT_0	-	Antitoxin
-	2127608..2127747	+	140	NuclAT_0	-	Antitoxin
DD555_RS11125	2127739..2127915	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DD555_RS11130	2128024..2128797	-	774	WP_000750412.1	staphylococcal enterotoxin type A	-
DD555_RS11135	2129170..2129544	-	375	WP_000340977.1	hypothetical protein	-
DD555_RS11140	2129600..2129887	-	288	WP_001262621.1	hypothetical protein	-
DD555_RS11145	2129933..2130085	-	153	WP_001000058.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / sea / hlb / groEL	2123978..2184763	60785

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T105117 WP_011447039.1 NZ_CP029166:c2127915-2127739 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T105117 NZ_CP029166:c2127915-2127739 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT105117 NZ_CP029166:2127608-2127747 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCGATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin