Detailed information of TA system TA105114

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1964619..1964801
• Replicon: chromosome
• Accession: NZ_CP029166
• Organism: Staphylococcus aureus strain SVH7513

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: DD555_RS10045
• Protein ID: WP_001801861.1
• Coordinates: 1964619..1964714 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1964742..1964801 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD555_RS09995	1960279..1960905	+	627	WP_000669046.1	hypothetical protein	-
DD555_RS10000	1960946..1961290	+	345	WP_000627551.1	DUF3969 family protein	-
DD555_RS10005	1961388..1961939	+	552	WP_000414205.1	hypothetical protein	-
DD555_RS10010	1962157..1962798	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
DD555_RS10015	1962912..1963097	-	186	WP_000809857.1	hypothetical protein	-
DD555_RS10020	1963099..1963275	-	177	WP_000375476.1	hypothetical protein	-
DD555_RS10025	1963286..1963669	-	384	WP_000070811.1	hypothetical protein	-
DD555_RS10035	1964273..1964416	-	144	WP_001549059.1	transposase	-
DD555_RS10045	1964619..1964714	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1964742..1964801	-	60	-	-	Antitoxin
DD555_RS10050	1964837..1964938	+	102	WP_001791893.1	hypothetical protein	-
DD555_RS10055	1964916..1965092	-	177	Protein_1881	transposase	-
DD555_RS10060	1965286..1965663	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	lukD / hlgA	1938594..2018467	79873

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T105114 WP_001801861.1 NZ_CP029166:1964619-1964714 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T105114 NZ_CP029166:1964619-1964714 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT105114 NZ_CP029166:c1964801-1964742 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin