Detailed information of TA system TA105110

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1633376..1633955
• Replicon: chromosome
• Accession: NZ_CP029166
• Organism: Staphylococcus aureus strain SVH7513

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: DD555_RS08335
• Protein ID: WP_001025401.1
• Coordinates: 1633710..1633955 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1633376..1633741 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD555_RS08295	1630119..1630676	-	558	WP_000645042.1	DUF2815 family protein	-
DD555_RS08300	1630702..1631868	-	1167	WP_084986307.1	DUF2800 domain-containing protein	-
DD555_RS08305	1631865..1632227	-	363	WP_084986306.1	hypothetical protein	-
DD555_RS08310	1632242..1632565	-	324	WP_000175001.1	hypothetical protein	-
DD555_RS08315	1632644..1632805	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
DD555_RS08320	1632818..1633081	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
DD555_RS08325	1633106..1633321	-	216	WP_001097552.1	hypothetical protein	-
DD555_RS08330	1633376..1633741	+	366	WP_001128433.1	hypothetical protein	Antitoxin
DD555_RS08335	1633710..1633955	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
DD555_RS08340	1634011..1634220	+	210	WP_000642492.1	hypothetical protein	-
DD555_RS08345	1634210..1634353	-	144	WP_000939498.1	hypothetical protein	-
DD555_RS08350	1634382..1635158	-	777	WP_001148544.1	Rha family transcriptional regulator	-
DD555_RS08355	1635172..1635408	-	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DD555_RS08360	1635560..1635874	+	315	WP_000333630.1	helix-turn-helix domain-containing protein	-
DD555_RS08365	1635887..1636348	+	462	WP_000525004.1	hypothetical protein	-
DD555_RS08370	1636366..1636950	+	585	WP_000825948.1	hypothetical protein	-
DD555_RS08375	1637180..1637326	+	147	WP_001013104.1	hypothetical protein	-
DD555_RS08380	1637323..1637937	-	615	WP_000191459.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1593686..1652024	58338

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T105110 WP_001025401.1 NZ_CP029166:c1633955-1633710 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T105110 NZ_CP029166:c1633955-1633710 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT105110 NZ_CP029166:1633376-1633741 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin