105090

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2762720..2763222 Replicon chromosome
Accession NZ_CP029164
Organism Escherichia coli strain 104

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag DDV95_RS13995 Protein ID WP_000767829.1
Coordinates 2762968..2763222 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag DDV95_RS13990 Protein ID WP_001259255.1
Coordinates 2762720..2762971 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDV95_RS13960 2757892..2758959 - 1068 WP_000080097.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
DDV95_RS13965 2758959..2760029 - 1071 WP_000108970.1 histidinol-phosphate transaminase -
DDV95_RS13970 2760026..2761330 - 1305 WP_072686623.1 histidinol dehydrogenase -
DDV95_RS13975 2761336..2762235 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
DDV95_RS13985 2762387..2762437 - 51 WP_001364200.1 his operon leader peptide -
DDV95_RS13990 2762720..2762971 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
DDV95_RS13995 2762968..2763222 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
DDV95_RS14000 2763305..2764129 + 825 WP_075826841.1 SDR family oxidoreductase -
DDV95_RS14005 2764175..2765104 + 930 WP_001461145.1 LysR family transcriptional regulator -
DDV95_RS14010 2765319..2765381 + 63 WP_010723108.1 membrane protein YoeI -
DDV95_RS14015 2765371..2766729 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
DDV95_RS14020 2766908..2767966 + 1059 WP_000492315.1 transport protein YeeE -
DDV95_RS14025 2767980..2768207 + 228 WP_050867712.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T105090 WP_000767829.1 NZ_CP029164:2762968-2763222 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T105090 NZ_CP029164:2762968-2763222 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT105090 WP_001259255.1 NZ_CP029164:2762720-2762971 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT105090 NZ_CP029164:2762720-2762971 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References