Detailed information of TA system TA105081

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1087190..1087412
• Replicon: chromosome
• Accession: NZ_CP029164
• Organism: Escherichia coli strain 104

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: A0A829L523
• Locus tag: DDV95_RS05640
• Protein ID: WP_000170738.1
• Coordinates: 1087305..1087412 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1087190..1087256 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDV95_RS05615	1082631..1083533	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
DDV95_RS05620	1083544..1084527	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
DDV95_RS05625	1084524..1085528	+	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
DDV95_RS05630	1085558..1086829	-	1272	WP_001318103.1	amino acid permease	-
-	1087190..1087256	-	67	-	-	Antitoxin
DDV95_RS05640	1087305..1087412	+	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
DDV95_RS05650	1087788..1087895	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
DDV95_RS25925	1088271..1088378	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
DDV95_RS25685	1088754..1088861	+	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
DDV95_RS05675	1088948..1090627	-	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
DDV95_RS05680	1090624..1090815	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
DDV95_RS05685	1090812..1092383	-	1572	WP_001204944.1	cellulose biosynthesis protein BcsE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3864.67 Da
• Isoelectric Point: 9.0157

>T105081 WP_000170738.1 NZ_CP029164:1087305-1087412 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASLIVNWLNKRK

Nucleotide

• Length: 108 bp

>T105081 NZ_CP029164:1087305-1087412 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATAGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT105081 NZ_CP029164:c1087256-1087190 [Escherichia coli]
GTCTAGGTTCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A829L523

Antitoxin