Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 4868750..4869252 Replicon chromosome
Accession NZ_CP029111
Organism Escherichia coli strain AR436

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag CSC23_RS25575 Protein ID WP_000767829.1
Coordinates 4868998..4869252 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CSC23_RS25570 Protein ID WP_001610372.1
Coordinates 4868750..4869001 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC23_RS25535 4863928..4864995 - 1068 WP_000080141.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
CSC23_RS25540 4864995..4866065 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
CSC23_RS25545 4866062..4867366 - 1305 WP_001367667.1 histidinol dehydrogenase -
CSC23_RS25550 4867372..4868271 - 900 WP_000131792.1 ATP phosphoribosyltransferase -
CSC23_RS25560 4868417..4868467 - 51 WP_001364200.1 his operon leader peptide -
CSC23_RS25570 4868750..4869001 + 252 WP_001610372.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
CSC23_RS25575 4868998..4869252 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
CSC23_RS25580 4869335..4870159 + 825 WP_000754737.1 SDR family oxidoreductase -
CSC23_RS25585 4870205..4871134 + 930 WP_000803366.1 LysR family transcriptional regulator -
CSC23_RS25590 4871349..4871411 + 63 WP_010723108.1 membrane protein YoeI -
CSC23_RS25595 4871401..4872759 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
CSC23_RS25600 4872939..4873997 + 1059 WP_000492330.1 transport protein YeeE -
CSC23_RS25605 4874011..4874238 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T104928 WP_000767829.1 NZ_CP029111:4868998-4869252 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T104928 NZ_CP029111:4868998-4869252 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9289.55 Da        Isoelectric Point: 4.7954

>AT104928 WP_001610372.1 NZ_CP029111:4868750-4869001 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLIDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT104928 NZ_CP029111:4868750-4869001 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATAGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References