Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 791992..792250 Replicon chromosome
Accession NZ_CP029108
Organism Escherichia coli strain AR437

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag CSC24_RS05965 Protein ID WP_000809168.1
Coordinates 792098..792250 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 791992..792049 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC24_RS26290 787046..787822 + 777 WP_166666977.1 fimbria/pilus outer membrane usher protein -
CSC24_RS26295 787997..788371 + 375 WP_021521651.1 hypothetical protein -
CSC24_RS26040 788384..789342 + 959 Protein_735 fimbrial family protein -
CSC24_RS05955 789381..790280 - 900 WP_001300855.1 transcriptional activator NhaR -
CSC24_RS05960 790346..791512 - 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
- 791992..792049 - 58 - - Antitoxin
CSC24_RS05965 792098..792250 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
CSC24_RS05970 792354..793484 - 1131 WP_001118464.1 molecular chaperone DnaJ -
CSC24_RS05975 793573..795489 - 1917 WP_000516131.1 molecular chaperone DnaK -
CSC24_RS05980 795866..796270 + 405 WP_000843559.1 DUF2541 family protein -
CSC24_RS05985 796296..797009 + 714 WP_001102383.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T104881 WP_000809168.1 NZ_CP029108:792098-792250 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T104881 NZ_CP029108:792098-792250 [Escherichia coli]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT104881 NZ_CP029108:c792049-791992 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References