Detailed information of TA system TA104808

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2136287..2136586
• Replicon: chromosome
• Accession: NZ_CP029087
• Organism: Staphylococcus aureus strain AR461

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC47_RS11210
• Protein ID: WP_011447039.1
• Coordinates: 2136410..2136586 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2136287..2136342 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC47_RS11160	2131619..2131879	+	261	WP_001791826.1	hypothetical protein	-
CSC47_RS11165	2131932..2132282	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC47_RS11170	2132967..2133416	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC47_RS11175	2133511..2133846	-	336	Protein_2062	SH3 domain-containing protein	-
CSC47_RS11190	2134495..2134986	-	492	WP_000919350.1	staphylokinase	-
CSC47_RS11195	2135177..2135932	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSC47_RS11200	2135944..2136198	-	255	WP_000611512.1	phage holin	-
CSC47_RS11205	2136250..2136357	+	108	WP_001791821.1	hypothetical protein	-
-	2136279..2136418	+	140	NuclAT_0	-	-
-	2136279..2136418	+	140	NuclAT_0	-	-
-	2136279..2136418	+	140	NuclAT_0	-	-
-	2136279..2136418	+	140	NuclAT_0	-	-
-	2136287..2136342	+	56	-	-	Antitoxin
CSC47_RS11210	2136410..2136586	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC47_RS11215	2136736..2137032	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC47_RS11220	2137090..2137377	-	288	WP_001040261.1	hypothetical protein	-
CSC47_RS11225	2137424..2137576	-	153	WP_001153681.1	hypothetical protein	-
CSC47_RS11230	2137566..2141351	-	3786	WP_000582154.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2131932..2185450	53518

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T104808 WP_011447039.1 NZ_CP029087:c2136586-2136410 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T104808 NZ_CP029087:c2136586-2136410 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT104808 NZ_CP029087:2136287-2136342 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin