Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1982073..1982253 Replicon chromosome
Accession NZ_CP029087
Organism Staphylococcus aureus strain AR461

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag CSC47_RS10180 Protein ID WP_001801861.1
Coordinates 1982073..1982168 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1982196..1982253 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC47_RS10150 1977236..1977886 + 651 WP_001795210.1 excalibur calcium-binding domain-containing protein -
CSC47_RS10155 1977967..1978962 + 996 WP_000070642.1 DUF4352 domain-containing protein -
CSC47_RS10160 1979037..1979663 + 627 WP_000669024.1 hypothetical protein -
CSC47_RS10165 1979704..1980045 + 342 WP_000627540.1 DUF3969 family protein -
CSC47_RS10170 1980146..1980718 + 573 WP_000414216.1 hypothetical protein -
CSC47_RS10175 1980916..1981928 - 1013 Protein_1908 IS3 family transposase -
CSC47_RS10180 1982073..1982168 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1982196..1982253 - 58 - - Antitoxin
CSC47_RS10185 1982291..1982392 + 102 WP_001792025.1 hypothetical protein -
CSC47_RS10190 1982370..1982531 - 162 Protein_1911 transposase -
CSC47_RS10195 1982522..1983016 - 495 Protein_1912 transposase -
CSC47_RS10200 1983468..1984697 - 1230 WP_000072627.1 restriction endonuclease subunit S -
CSC47_RS10205 1984690..1986246 - 1557 WP_000028669.1 type I restriction-modification system subunit M -
CSC47_RS10210 1986410..1986544 - 135 WP_001791797.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA / selk 1976478..2050537 74059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T104804 WP_001801861.1 NZ_CP029087:1982073-1982168 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T104804 NZ_CP029087:1982073-1982168 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 58 bp

>AT104804 NZ_CP029087:c1982253-1982196 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References