Detailed information of TA system TA104801

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1605458..1606037
• Replicon: chromosome
• Accession: NZ_CP029087
• Organism: Staphylococcus aureus strain AR461

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: CSC47_RS08115
• Protein ID: WP_001025401.1
• Coordinates: 1605792..1606037 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1605458..1605823 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC47_RS08075	1602201..1602758	-	558	WP_000645045.1	DUF2815 family protein	-
CSC47_RS08080	1602784..1603950	-	1167	WP_000762530.1	DUF2800 domain-containing protein	-
CSC47_RS08085	1603947..1604309	-	363	WP_108711060.1	hypothetical protein	-
CSC47_RS08090	1604324..1604647	-	324	WP_000174998.1	hypothetical protein	-
CSC47_RS08095	1604726..1604887	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
CSC47_RS08100	1604900..1605163	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
CSC47_RS08105	1605188..1605403	-	216	WP_001097552.1	hypothetical protein	-
CSC47_RS08110	1605458..1605823	+	366	WP_001128433.1	hypothetical protein	Antitoxin
CSC47_RS08115	1605792..1606037	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
CSC47_RS08120	1606104..1606484	+	381	WP_000773059.1	DUF2513 domain-containing protein	-
CSC47_RS08125	1606471..1606668	-	198	WP_001148860.1	hypothetical protein	-
CSC47_RS08130	1606738..1606950	+	213	WP_000362644.1	hypothetical protein	-
CSC47_RS15385	1606991..1607140	-	150	WP_000771849.1	hypothetical protein	-
CSC47_RS08135	1607155..1607598	-	444	WP_000435357.1	hypothetical protein	-
CSC47_RS08140	1607646..1607858	-	213	WP_000213811.1	helix-turn-helix transcriptional regulator	-
CSC47_RS08145	1608010..1608741	+	732	WP_020807995.1	XRE family transcriptional regulator	-
CSC47_RS08150	1608811..1608993	+	183	WP_000705240.1	hypothetical protein	-
CSC47_RS08155	1609029..1609175	+	147	WP_001795334.1	hypothetical protein	-
CSC47_RS08160	1609172..1609786	-	615	WP_000191466.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1565967..1673765	107798

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T104801 WP_001025401.1 NZ_CP029087:c1606037-1605792 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T104801 NZ_CP029087:c1606037-1605792 [Staphylococcus aureus]
ATGAACATTCAAGAAGCAACTAAGATAGCTACAAAAAATCTTGTCTCTATGACACGGAAAGATTGGAAAGAAAGTCATCG
AACTAAGATATTACCAACAAATGATAGTTTTTTACAATGCATCATTTCAAATAGCGATGGGACAAACCTTATCAGATATT
GGCAACCTTCAGCCGATGACCTCATGGCAAATGATTGGGAAGTTATAAACCCAACTAGAGACCAGGAATTATTGAAGCAA
TTTTAG

Antitoxin

Nucleotide

• Length: 366 bp

>AT104801 NZ_CP029087:1605458-1605823 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin