Detailed information of TA system TA104788

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 563145..563452
• Replicon: chromosome
• Accession: NZ_CP029086
• Organism: Staphylococcus aureus strain AR462

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC48_RS03095
• Protein ID: WP_011447039.1
• Coordinates: 563276..563452 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	563145..563284 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC48_RS03035	558712..558891	+	180	WP_000669791.1	hypothetical protein	-
CSC48_RS03045	559202..559462	+	261	WP_001791826.1	hypothetical protein	-
CSC48_RS03050	559515..559865	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC48_RS03055	560375..560710	-	336	Protein_517	SH3 domain-containing protein	-
CSC48_RS03075	561361..561852	-	492	WP_000920038.1	staphylokinase	-
CSC48_RS03080	562043..562798	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSC48_RS03085	562810..563064	-	255	WP_000611512.1	phage holin	-
CSC48_RS03090	563116..563223	+	108	WP_031762631.1	hypothetical protein	-
-	563145..563284	+	140	NuclAT_0	-	Antitoxin
-	563145..563284	+	140	NuclAT_0	-	Antitoxin
-	563145..563284	+	140	NuclAT_0	-	Antitoxin
-	563145..563284	+	140	NuclAT_0	-	Antitoxin
CSC48_RS03095	563276..563452	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC48_RS03100	563655..564428	-	774	WP_025174055.1	staphylococcal enterotoxin type P	-
CSC48_RS03105	564849..565223	-	375	WP_000340977.1	hypothetical protein	-
CSC48_RS03110	565279..565566	-	288	WP_001040255.1	hypothetical protein	-
CSC48_RS03115	565613..565765	-	153	WP_000654329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / see / hlb / groEL	559515..613230	53715

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T104788 WP_011447039.1 NZ_CP029086:c563452-563276 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T104788 NZ_CP029086:c563452-563276 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT104788 NZ_CP029086:563145-563284 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin