Detailed information of TA system TA104783

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2724094..2724401
• Replicon: chromosome
• Accession: NZ_CP029084
• Organism: Staphylococcus aureus strain AR464

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC49_RS14075
• Protein ID: WP_011447039.1
• Coordinates: 2724225..2724401 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2724094..2724233 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC49_RS14030	2719434..2719694	+	261	WP_001791826.1	hypothetical protein	-
CSC49_RS14035	2719747..2720097	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC49_RS14040	2720781..2721230	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC49_RS14045	2721325..2721660	-	336	Protein_2585	SH3 domain-containing protein	-
CSC49_RS14055	2722310..2722801	-	492	WP_000919350.1	staphylokinase	-
CSC49_RS14060	2722992..2723747	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSC49_RS14065	2723759..2724013	-	255	WP_000611512.1	phage holin	-
CSC49_RS14070	2724065..2724172	+	108	WP_001791821.1	hypothetical protein	-
-	2724094..2724233	+	140	NuclAT_0	-	Antitoxin
-	2724094..2724233	+	140	NuclAT_0	-	Antitoxin
-	2724094..2724233	+	140	NuclAT_0	-	Antitoxin
-	2724094..2724233	+	140	NuclAT_0	-	Antitoxin
CSC49_RS14075	2724225..2724401	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC49_RS14080	2724551..2724847	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC49_RS14085	2724905..2725192	-	288	WP_001040261.1	hypothetical protein	-
CSC49_RS14090	2725239..2725391	-	153	WP_001153681.1	hypothetical protein	-
CSC49_RS14095	2725381..2729166	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	map / hlb / scn / chp / sak / hlb / groEL	2715917..2773056	57139

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T104783 WP_011447039.1 NZ_CP029084:c2724401-2724225 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T104783 NZ_CP029084:c2724401-2724225 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT104783 NZ_CP029084:2724094-2724233 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin