Detailed information of TA system TA104767

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1704957..1705295
• Replicon: chromosome
• Accession: NZ_CP029082
• Organism: Staphylococcus aureus strain AR465

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC50_RS09085
• Protein ID: WP_011447039.1
• Coordinates: 1704957..1705133 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1705121..1705295 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC50_RS09065	1700192..1703977	+	3786	WP_000582154.1	hypothetical protein	-
CSC50_RS09070	1703967..1704119	+	153	WP_031864465.1	hypothetical protein	-
CSC50_RS09075	1704166..1704453	+	288	WP_001040261.1	hypothetical protein	-
CSC50_RS09080	1704511..1704807	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC50_RS09085	1704957..1705133	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	1705121..1705295	-	175	-	-	Antitoxin
CSC50_RS09095	1705345..1705599	+	255	WP_000611512.1	phage holin	-
CSC50_RS09100	1705611..1706366	+	756	WP_000861038.1	CHAP domain-containing protein	-
CSC50_RS09105	1706557..1707048	+	492	WP_000919350.1	staphylokinase	-
CSC50_RS09120	1707698..1708033	+	336	Protein_1665	SH3 domain-containing protein	-
CSC50_RS09125	1708128..1708577	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC50_RS09130	1709262..1709612	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC50_RS09135	1709665..1709925	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sak / chp / scn / hlb	1665044..1710987	45943

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T104767 WP_011447039.1 NZ_CP029082:1704957-1705133 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T104767 NZ_CP029082:1704957-1705133 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT104767 NZ_CP029082:c1705295-1705121 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin