Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 1203720..1203904 Replicon chromosome
Accession NZ_CP029082
Organism Staphylococcus aureus strain AR465

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag CSC50_RS06195 Protein ID WP_000482652.1
Coordinates 1203720..1203827 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 1203844..1203904 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC50_RS06170 1199082..1199555 + 474 WP_000456486.1 GyrI-like domain-containing protein -
CSC50_RS06175 1199678..1200889 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
CSC50_RS06180 1201071..1201730 - 660 WP_000831298.1 membrane protein -
CSC50_RS06185 1201790..1202932 - 1143 WP_001176863.1 glycerate kinase -
CSC50_RS06190 1203200..1203586 + 387 WP_000779360.1 flippase GtxA -
CSC50_RS06195 1203720..1203827 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 1203844..1203904 - 61 - - Antitoxin
CSC50_RS06205 1204530..1206293 + 1764 WP_001064825.1 ABC transporter ATP-binding protein/permease -
CSC50_RS06210 1206318..1208051 + 1734 WP_000486487.1 ABC transporter ATP-binding protein/permease -
CSC50_RS06220 1208282..1208449 + 168 Protein_1127 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T104758 WP_000482652.1 NZ_CP029082:1203720-1203827 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T104758 NZ_CP029082:1203720-1203827 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT104758 NZ_CP029082:c1203904-1203844 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References