Detailed information of TA system TA104752

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 2472544..2472851
• Replicon: chromosome
• Accession: NZ_CP029080
• Organism: Staphylococcus aureus strain AR466

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: CSC51_RS12695
• Protein ID: WP_011447039.1
• Coordinates: 2472675..2472851 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	2472544..2472683 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC51_RS12650	2467884..2468144	+	261	WP_001791826.1	hypothetical protein	-
CSC51_RS12655	2468197..2468547	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
CSC51_RS12660	2469231..2469680	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
CSC51_RS12665	2469775..2470110	-	336	Protein_2334	SH3 domain-containing protein	-
CSC51_RS12675	2470760..2471251	-	492	WP_000919350.1	staphylokinase	-
CSC51_RS12680	2471442..2472197	-	756	WP_000861038.1	CHAP domain-containing protein	-
CSC51_RS12685	2472209..2472463	-	255	WP_000611509.1	phage holin	-
CSC51_RS12690	2472515..2472622	+	108	WP_001791821.1	hypothetical protein	-
-	2472544..2472683	+	140	NuclAT_0	-	Antitoxin
-	2472544..2472683	+	140	NuclAT_0	-	Antitoxin
-	2472544..2472683	+	140	NuclAT_0	-	Antitoxin
-	2472544..2472683	+	140	NuclAT_0	-	Antitoxin
CSC51_RS12695	2472675..2472851	-	177	WP_011447039.1	putative holin-like toxin	Toxin
CSC51_RS12700	2473001..2473297	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
CSC51_RS12705	2473355..2473642	-	288	WP_001040261.1	hypothetical protein	-
CSC51_RS12710	2473689..2473841	-	153	WP_001153681.1	hypothetical protein	-
CSC51_RS12715	2473831..2477616	-	3786	WP_108703213.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2468197..2518479	50282

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T104752 WP_011447039.1 NZ_CP029080:c2472851-2472675 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T104752 NZ_CP029080:c2472851-2472675 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT104752 NZ_CP029080:2472544-2472683 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin