104709

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 2181787..2182655 Replicon chromosome
Accession NZ_CP029065
Organism Mycobacterium tuberculosis strain TBMENG-03

Toxin (Protein)


Gene name higB Uniprot ID P9WJA4
Locus tag DDF83_RS10595 Protein ID WP_010886136.1
Coordinates 2181787..2182164 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID G0TLM0
Locus tag DDF83_RS10600 Protein ID WP_003409886.1
Coordinates 2182206..2182655 (+) Length 150 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDF83_RS10540 2177230..2177421 + 192 Protein_1993 hypothetical protein -
DDF83_RS10545 2177576..2178028 - 453 WP_003899095.1 lipoprotein -
DDF83_RS10550 2178092..2178493 + 402 WP_003409869.1 hypothetical protein -
DDF83_RS10555 2178486..2178668 - 183 WP_003409870.1 hypothetical protein -
DDF83_RS10560 2178782..2179132 - 351 WP_003409871.1 hypothetical protein -
DDF83_RS10565 2179143..2180045 - 903 WP_003409874.1 hypothetical protein -
DDF83_RS10570 2180066..2180257 - 192 WP_003409876.1 hypothetical protein -
DDF83_RS10575 2180258..2180554 - 297 WP_003409877.1 hypothetical protein -
DDF83_RS10580 2180794..2181009 + 216 WP_003409878.1 antitoxin -
DDF83_RS10585 2181006..2181317 + 312 WP_003409881.1 type II toxin-antitoxin system VapC family toxin -
DDF83_RS21395 2181291..2181812 - 522 WP_003904745.1 hypothetical protein -
DDF83_RS10595 2181787..2182164 + 378 WP_010886136.1 type II toxin-antitoxin system toxin HigB Toxin
DDF83_RS10600 2182206..2182655 + 450 WP_003409886.1 type II toxin-antitoxin system antitoxin HigA Antitoxin
DDF83_RS10605 2182652..2183197 + 546 WP_003409891.1 SecB-like chaperone -
DDF83_RS10610 2183086..2183700 - 615 WP_003901296.1 hypothetical protein -
DDF83_RS10615 2183749..2184045 - 297 WP_003409896.1 type II toxin-antitoxin system RelE/ParE family toxin -
DDF83_RS10620 2184042..2184293 - 252 WP_003409899.1 type II toxin-antitoxin system ParD family antitoxin -
DDF83_RS10625 2184280..2184774 + 495 WP_003899099.1 hypothetical protein -
DDF83_RS10630 2184934..2185341 - 408 WP_003409913.1 type II toxin-antitoxin system VapC family toxin -
DDF83_RS10635 2185345..2185617 - 273 WP_003899100.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
DDF83_RS10640 2185650..2186870 - 1221 WP_003409919.1 TetR family transcriptional regulator Mce3R -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(27-113)

Antitoxin

Cro/C1-type helix-turn-helix domain

(44-91)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14397.77 Da        Isoelectric Point: 10.8862

>T104709 WP_010886136.1 NZ_CP029065:2181787-2182164 [Mycobacterium tuberculosis]
VPPPDPAAMGTWKFFRASVDGRPVFKKEFDKLPDQARAALIVLMQRYLVGDLAAGSIKPIRGDILELRWHEANNHFRVLF
FRWGQHPVALTAFYKNQQKTPKTKIETALDRQKIWKRAFGDTPPI

Download         Length: 378 bp

>T104709 NZ_CP029065:2181787-2182164 [Mycobacterium tuberculosis]
GTGCCGCCCCCTGATCCAGCCGCCATGGGTACCTGGAAGTTCTTCCGGGCATCTGTGGATGGCCGGCCGGTATTCAAGAA
GGAGTTCGACAAGCTTCCTGATCAGGCCCGGGCCGCGCTGATCGTGCTAATGCAGCGGTATCTCGTCGGCGACCTCGCCG
CAGGGAGCATCAAACCGATTCGTGGCGACATTCTGGAGTTGCGATGGCATGAGGCGAACAACCACTTCCGGGTACTGTTC
TTCCGCTGGGGCCAGCATCCCGTAGCGCTGACAGCGTTCTACAAGAACCAGCAGAAGACTCCCAAGACGAAGATCGAGAC
GGCCCTGGACCGGCAGAAAATCTGGAAAAGAGCCTTCGGCGACACCCCACCGATCTGA

Antitoxin


Download         Length: 150 a.a.        Molecular weight: 16760.16 Da        Isoelectric Point: 8.0771

>AT104709 WP_003409886.1 NZ_CP029065:2182206-2182655 [Mycobacterium tuberculosis]
MSIDFPLGDDLAGYIAEAIAADPSFKGTLEDAEEARRLVDALIALRKHCQLSQVEVAKRMGVRQPTVSGFEKEPSDPKLS
TLQRYARALDARLRLVLEVPTLREVPTWHRLSSYRGSARDHQVRVGADKEILMQTNWARHISVRQVEVA

Download         Length: 450 bp

>AT104709 NZ_CP029065:2182206-2182655 [Mycobacterium tuberculosis]
ATGAGCATTGACTTCCCTTTGGGTGACGACCTCGCCGGCTATATTGCCGAGGCGATTGCGGCTGATCCCAGCTTCAAAGG
CACTCTCGAAGACGCCGAGGAGGCACGCAGGCTGGTCGATGCGCTGATTGCGCTGCGCAAGCACTGCCAGCTGAGCCAGG
TTGAGGTTGCTAAGCGTATGGGGGTGCGCCAGCCCACCGTGAGCGGTTTCGAGAAGGAACCCAGCGACCCCAAACTGTCT
ACGCTGCAACGTTATGCCCGTGCATTGGACGCCCGGCTGCGGCTGGTGCTCGAAGTTCCCACGCTTCGCGAAGTGCCTAC
GTGGCATCGGCTCTCCTCTTATCGGGGCTCCGCACGGGACCACCAGGTCCGGGTGGGTGCAGACAAGGAAATCCTGATGC
AGACGAACTGGGCCCGCCACATTTCGGTTCGGCAGGTTGAGGTGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AWK
PDB 7NBU

Antitoxin

Source ID Structure
AlphaFold DB G0TLM0

References