104661

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4202158..4202851 Replicon chromosome
Accession NZ_CP029057
Organism Escherichia coli strain FORC_081

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag FORC81_RS20565 Protein ID WP_000415584.1
Coordinates 4202158..4202454 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag FORC81_RS20570 Protein ID WP_000650107.1
Coordinates 4202456..4202851 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FORC81_RS20530 4197246..4197560 - 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -
FORC81_RS20535 4197591..4198172 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
FORC81_RS20540 4198491..4198823 + 333 WP_000917684.1 DUF2645 family protein -
FORC81_RS20545 4198869..4200218 - 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
FORC81_RS20550 4200215..4200874 - 660 WP_001221493.1 two-component system response regulator QseB -
FORC81_RS20555 4201026..4201418 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
FORC81_RS20560 4201471..4201953 + 483 WP_000183505.1 transcriptional regulator -
FORC81_RS20565 4202158..4202454 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
FORC81_RS20570 4202456..4202851 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
FORC81_RS20575 4202984..4204591 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
FORC81_RS20580 4204729..4206987 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T104661 WP_000415584.1 NZ_CP029057:4202158-4202454 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T104661 NZ_CP029057:4202158-4202454 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT104661 WP_000650107.1 NZ_CP029057:4202456-4202851 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT104661 NZ_CP029057:4202456-4202851 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References