Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2586930..2587453 Replicon chromosome
Accession NZ_CP029032
Organism Staphylococcus aureus strain OXLIM

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag DDG65_RS13630 Protein ID WP_000074048.1
Coordinates 2586930..2587196 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag DDG65_RS13635 Protein ID WP_000587616.1
Coordinates 2587196..2587453 (-) Length 86 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDG65_RS13610 2582237..2583424 - 1188 WP_000026194.1 MFS transporter -
DDG65_RS13615 2583820..2584596 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
DDG65_RS13620 2584589..2585251 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
DDG65_RS13625 2585499..2586575 - 1077 WP_001076671.1 M42 family metallopeptidase -
DDG65_RS13630 2586930..2587196 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
DDG65_RS13635 2587196..2587453 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
DDG65_RS13640 2587559..2587753 - 195 WP_001790145.1 hypothetical protein -
DDG65_RS13645 2587812..2588267 + 456 WP_000732082.1 DUF1307 domain-containing protein -
DDG65_RS13650 2588435..2590012 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
DDG65_RS13655 2590207..2590956 + 750 WP_000072444.1 hypothetical protein -
DDG65_RS13660 2591180..2592373 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(25-87)

Antitoxin

(1-68)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T104632 WP_000074048.1 NZ_CP029032:c2587196-2586930 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T104632 NZ_CP029032:c2587196-2586930 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT104632 WP_000587616.1 NZ_CP029032:c2587453-2587196 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT104632 NZ_CP029032:c2587453-2587196 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z


Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References