Detailed information of TA system TA104621

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2090217..2090516
• Replicon: chromosome
• Accession: NZ_CP029032
• Organism: Staphylococcus aureus strain OXLIM

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: DDG65_RS10865
• Protein ID: WP_011447039.1
• Coordinates: 2090340..2090516 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2090217..2090272 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDG65_RS10820	2085548..2085808	+	261	WP_001791826.1	hypothetical protein	-
DDG65_RS10825	2085861..2086211	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
DDG65_RS10830	2086896..2087345	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
DDG65_RS10835	2087440..2087775	-	336	Protein_2002	SH3 domain-containing protein	-
DDG65_RS10845	2088425..2088916	-	492	WP_000919350.1	staphylokinase	-
DDG65_RS10850	2089107..2089862	-	756	WP_000861038.1	CHAP domain-containing protein	-
DDG65_RS10855	2089874..2090128	-	255	WP_000611512.1	phage holin	-
DDG65_RS10860	2090180..2090287	+	108	WP_001791821.1	hypothetical protein	-
-	2090209..2090348	+	140	NuclAT_0	-	-
-	2090209..2090348	+	140	NuclAT_0	-	-
-	2090209..2090348	+	140	NuclAT_0	-	-
-	2090209..2090348	+	140	NuclAT_0	-	-
-	2090217..2090272	+	56	-	-	Antitoxin
DDG65_RS10865	2090340..2090516	-	177	WP_011447039.1	putative holin-like toxin	Toxin
DDG65_RS10870	2090666..2090962	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
DDG65_RS10875	2091020..2091307	-	288	WP_001040261.1	hypothetical protein	-
DDG65_RS10880	2091354..2091506	-	153	WP_001153681.1	hypothetical protein	-
DDG65_RS10885	2091496..2095281	-	3786	WP_000582165.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2085861..2144829	58968

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T104621 WP_011447039.1 NZ_CP029032:c2090516-2090340 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T104621 NZ_CP029032:c2090516-2090340 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT104621 NZ_CP029032:2090217-2090272 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin