Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2222058..2222321 Replicon chromosome
Accession NZ_CP029030
Organism Staphylococcus aureus strain CAR

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag DC427_RS11540 Protein ID WP_001802298.1
Coordinates 2222217..2222321 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2222058..2222222 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DC427_RS11520 2218241..2218906 - 666 WP_001024094.1 SDR family oxidoreductase -
DC427_RS11525 2219058..2219378 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
DC427_RS11530 2219380..2220360 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
DC427_RS11535 2220626..2221717 + 1092 WP_000495671.1 lytic regulatory protein -
- 2222058..2222222 + 165 - - Antitoxin
DC427_RS11540 2222217..2222321 - 105 WP_001802298.1 hypothetical protein Toxin
DC427_RS14750 2222482..2222965 - 484 Protein_2132 recombinase family protein -
DC427_RS11550 2223008..2224144 - 1137 WP_000115564.1 SAP domain-containing protein -
DC427_RS11555 2224433..2224525 + 93 WP_001790138.1 hypothetical protein -
DC427_RS11560 2225230..2226087 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
DC427_RS11565 2226155..2226937 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T104596 WP_001802298.1 NZ_CP029030:c2222321-2222217 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T104596 NZ_CP029030:c2222321-2222217 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT104596 NZ_CP029030:2222058-2222222 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References